Study Explores Sleep Apnea, Autoimmune Disease Link

Summary: Poor sleep and inadequate oxygen supply associated with obstructive sleep apnea appears to affect cytokines. This could explain the link between OSA and an increased risk of autoimmune disorders, such as rheumatoid arthritis.

Source: University of Georgia

New research by University of Georgia scientists sheds light on why people with obstructive sleep apnea may have associated autoimmune disorders. The results could lead to better approaches to treatment and possibly new drug therapies.

The study, led by Bradley Phillips, builds on previous research showing that obstructive sleep apnea increases the risk for autoimmune diseases. Immune system disorders are a result of either low activity or over activity of the immune system and include well known conditions such as lupus and rheumatoid arthritis.

“This paper looks at what may be the underlying mechanisms that increase someone’s risk for autoimmune disorders because they have untreated obstructive sleep apnea,” said Phillips, director of UGA’s Biomedical and Health Sciences Institute.

Obstructive sleep apnea, or OSA, is a disorder that occurs when throat muscles relax temporarily, narrowing or collapsing the airway and momentarily cutting off breathing during sleep. The main treatment for OSA is continuous positive airway pressure, or CPAP, which pumps air through a mask to keep the airway open. About 40% of patients can’t tolerate CPAP.

OSA damages the health of 35% of Americans and results in increased risk of several autoimmune disorders, like rheumatoid arthritis and psoriasis, for example, but the molecular links to autoimmunity are poorly understood.

Phillips and the team looked at four cytokines–proteins involved in cell signaling–associated with autoimmune disease. They evaluated the cytokines in three groups of adults: patients with untreated OSA, patients with OSA who were receiving treatment, and people who did not have OSA. The study results revealed abnormal levels of the four cytokines in patients with untreated sleep apnea, suggesting that poor sleep and inadequate oxygen supply may affect the cytokines.

This study, published in Clinical Immunology, is one of four investigating possible links between obstructive sleep apnea and specific diseases. In addition to autoimmune disorders, the team is also looking at neurodegenerative disorders, cardiovascular disease and renal disease.

Study Explores Sleep Apnea, Autoimmune Disease Link

The main treatment for OSA is continuous positive airway pressure, or CPAP, which pumps air through a mask to keep the airway open. About 40% of patients can’t tolerate CPAP. Image is in the public domain

“The relationship between OSA and other diseases is always complex to study. OSA in adults is commonly first diagnosed in midlife, but increases with age,” said Phillips, professor in the College of Pharmacy. “With increased age, you are also at risk for other diseases, and it’s very challenging for clinicians and researchers to determine if it’s OSA alone that causes other disorders, or if OSA only worsens the severity and progression of an underlying disease. In the case of high blood pressure, we know untreated OSA can cause hypertension and make blood pressure drug therapy ineffective. If obstructive sleep apnea is a key player, then it should be evaluated and treated along with other conditions.”

The team conducted its research at UGA’s Clinical and Translational Research Unit, where Phillips is director. CTRU is part of the Georgia Clinical & Translational Science Alliance, a multi-institutional partnership between UGA, Emory University, the Morehouse School of Medicine and the Georgia Institute of Technology that leverages their complementary strengths to accelerate clinical and translational research, education and community engagement to impact health in Georgia. Phillips serves as UGA’s principal investigator for Georgia CTSA.

Co-authors on the study include Ye Wang, a Ph.D. student in statistics; Suresh Ambati, assistant research scientist in genetics; Ping Ma, professor in statistics; and Richard Meagher, Distinguished Research Professor of genetics. All are part of the Franklin College of Arts and Sciences.

Funding: For this project, Meagher, Ambati and Phillips were supported by the National Center for Advancing Translational Sciences of the National Institutes of Health under award No. UL1TR002378 and UGA’s Clinical and Translational Research Unit. Wang and Ma were supported by National Science Foundation grants DMS 1925066, NSF grants DMS 1903226, and NIH grants R01 GM122080.

About this neurology research news

Source: University of GeorgiaContact: Bradley Phillips – University of Georgia
Image: The image is in the public domain

Original Research: Closed access.
“Airways therapy of obstructive sleep apnea dramatically improves aberrant levels of soluble cytokines involved in autoimmune disease” by Bradley Phillips et al. Clinical Immunology


Abstract

Airways therapy of obstructive sleep apnea dramatically improves aberrant levels of soluble cytokines involved in autoimmune disease

Obstructive Sleep Apnea (OSA) damages the health of 35% of adult Americans. Disordered sleep results in increased risk of several autoimmune disorders, but the molecular links to autoimmunity are poorly understood. Herein, we identified four cytokines associated with autoimmune disease, whose median serum levels were significantly different for OSA patients receiving airways therapy, from the levels in untreated OSA patients, APRIL (5.2-fold lower, p = 3.5 × 10−11), CD30 (1.6-fold higher, p = 7.7 × 10−5), IFN-Alpha-2 (2.9-fold higher, p = 9.6 × 10−14) and IL-2 (1.9-fold higher, p = 0.0003). Cytokine levels in airways treated patients were similar to the levels in control subjects. t-SNE and UMAP analysis of these high dimensional patient cytokine data identified only two groups, suggesting a similar global response for all four cytokines to airways therapy. Our findings suggest the levels of these four cytokines may be altered by disordered sleep and perhaps by chronic hypoxia. Therapeutic options are discussed.

News Related

OTHER NEWS

I’m an expert and these are the 4 signs your bloating is not normal

BLOATING is something we all experience from time to time – especially after a large Sunday lunch. And while usually it goes away on its own, without much trouble, it ... Read more »

The 10 signs you’re at risk of a mental breakdown after Louise Thompson opens up

WHEN Louise Thompson shared her mental breakdown on social media earlier this week, her extremely honest video shocked many of her fans who believed the reality TV star was on ... Read more »

The sex positions most and least likely to give you a UTI revealed

SOMETIMES the memory of a steamy sex session is tainted by the arrival of a woman’s worst enemy – a UTI. Urinary tract infections (UTI) can happen to anyone of ... Read more »

30-Year-Old Woman Had Double Pregnancy with One-Month Interval; Is ‘Superfetation’ Dangerous?

(Photo : Pexels/Стас Ксензов) Babies born from superfetation are frequently considered twins as they may be born during the same birth on the same day. In March last year, Cara ... Read more »

Bypolls: Counting of votes underway in three Lok Sabha, seven Assembly seats

Representational image. PTI New Delhi: Counting of votes is underway on Sunday in three Lok Sabha and seven Assembly seats spread across five states and Delhi where bypolls were held ... Read more »

Nebula NGC 2392 Seems to Send a Creepy Message as Its Sonification Goes Viral; Can You Depict It?

There are ways to “hear” cosmic objects even if nobody can hear you scream in space – thanks to an airless vacuum. NASA can help people hear the heavenly symphony ... Read more »

Hundreds of Birds Die in Martha’s Vineyard; Has This Been Caused by Bird Flu That Also Spread Fast in Scotland in Early June?

(Photo : RODGER BOSCH/AFP via Getty Images) Hundreds of bird deaths have been occurring in Massachusetts and a local animal control organization suspects it’s because of bird flu. Hundreds of ... Read more »

How consumption of stale food may lead to foodborne illness caused by bacteria, viruses, parasites

Representaional Image by Mohamed Hassan from Pixabay Foodborne diseases are illnesses that result from the ingestion of contaminated food. More than 250 different foodborne hazards have been recognised including bacteria, ... Read more »

Mysterious Star Survives a Thermonuclear Supernova Explosion

The Hubble Space Telescope captured this dramatic spiral galaxy, cataloged as NGC 1309. Credit: NASA, ESA, The Hubble Heritage Team, (STScI/AURA) and A. Riess (STScI) A Tenacious Star Validates a ... Read more »

This 10-second test could measure your risk of death, study says

Scientists may have found a way to measure your risk of death. A new study published in the British Journal of Sports Medicine posits that a 10-second balance test could ... Read more »

Making art through computation

Master’s student Chelsi Cocking combines her love for computer science and design in her research and outreach efforts at the Media Lab. Read more »

Louisiana Man Contracted Necrotizing Fasciitis From Flesh-Eating Bacteria Vibrio Vulnificus, Recovering in Intensive Care Unit

(Photo : Pixabay/geralt) Flesh-Eating Bacteria Showing Up Earlier This Year, Infecting A Man From Louisiana Certain bacteria could cause the flesh-eating disease known as necrotizing fasciitis. Although the disease might ... Read more »

South Australian teenagers celebrate centenarians through portrait project

There's not much 109-year-old Catherina van der Linden hasn't seen in her long life, but a portrait of herself is one thing. Key points: The portrait project has already rolled out ... Read more »

Megalodon Shark Is the Deadliest Apex Predator That Ever Ruled the Oceans, Study Suggests

(Photo : FREDERIC J. BROWN/AFP via Getty Images) A life size replica of the Megalodon Shark which roamed the open seas 15-13 million years ago moves across the screen during ... Read more »

4-Billion-Year-Old Crystals Offer Clues to When Plate Tectonics Began, Setting Stage for Life on Earth

Artist’s illustration of uninhabitable conditions during the Hadean, an early geologic eon of Earth history. Credit: Alec Brenner Zircons (and the Secrets They Hold) Are Forever Scientists have long known ... Read more »

NSW, ACT announce free newborn testing for two rare disorders from July 1

In an Australian first, all NSW and ACT babies will be offered free testing for two rare but potentially fatal genetic disorders. From July 1, parents of all new babies ... Read more »

Artificial Photosynthesis Can Produce Food in Complete Darkness

Plants are growing in complete darkness in an acetate medium that replaces biological photosynthesis. Credit: Marcus Harland-Dunaway/UCR Artificial photosynthesis is being developed by researchers to help make food production more ... Read more »

From health checks to vaccines – Dr Jeff answers your health questions

DR JEFF FOSTER is The Sun on Sunday’s new resident doctor and is here to help YOU. Dr Jeff, 43, splits his time between working as a GP in Leamington ... Read more »

Theta Waves: A Marker of Emotional Regulation

Summary: Emotional regulation was linked to theta wave activity in the frontal cortex of the brain. Source: University of Montreal Without realizing it, we all rely on emotional regulation many ... Read more »

Black People in the Us Twice as Likely to Face Coercion, Unconsented Procedures During Birth

Summary: Black women in the US are twice as likely to be coerced into procedures during perinatal and birth, and to undergo them without explicit consent compared to white women. ... Read more »

Biden must take stronger action on abortion, Senate Democrats say

President Biden addresses the nation Friday following the U.S. Supreme Court’s decision to overturn Roe v. Wade. Mandel Ngan/AFP via Getty Images hide caption toggle caption Mandel Ngan/AFP via Getty ... Read more »

How woman’s dream of being a mother was taken from her

Ashleigh Roser was 33 years old when she was told becoming a mother was not something she could do. The Hunter Valley resident was diagnosed with endometrial cancer in 2019 ... Read more »

Alzheimer’s Disease Affects Most Known Biological Pathways in the Brain

Summary: Out of 341 known biological pathways, 91% are linked to Alzheimer’s disease. Source: Beth Israel Deaconess Medical Center Nearly 6 million older adults have Alzheimer’s disease in the United ... Read more »

First Evidence of Replay During Sleep in the Human Motor Cortex, Which Governs Voluntary Movement

Summary: Data collected from a tetraplegic man learning a BCI to play Simon showed the brain replays the learned information during sleep. Source: Mass General Why do we sleep? Scientists ... Read more »

Impostor Syndrome: When Self-Doubt Gets the Upper Hand

Summary: Impostor syndrome, or a fear that a person’s abilities will be exposed as a “deception”, can appear regardless of age, gender, or level of intelligence. Source: Martin Luther University ... Read more »

The Origins of Our Blood May Not Be What We Thought

Clusters of the earliest hematopoietic cells being born in the walls of the umbilical artery of a mouse embryo. The cells colored in red represent embryonic multipotent progenitor cells (eMPPs). ... Read more »

WHO says monkeypox does not constitute a public health emergency

The World Health Organization announced Saturday that the global monkeypox outbreak does not constitute a public health emergency of international concern for the time being, WHO convened an emergency committee ... Read more »

App replaces sleeping pills for insomniacs

Insomnia patients should ditch the drugs and sign up to an Australian-designed app to help them improve their sleep patterns. That's according to Britain's National Health Service (NHS), which has ... Read more »

Flu Vaccination Linked to 40% Lower Risk of Alzheimer’s Disease

A new study finds that flu vaccination was associated with a 40% reduced risk for Alzheimer’s disease over a four-year period. Over the course of four years, those who received ... Read more »

UK to offer vaccines to some gay, bisexual men for monkeypox

LONDON – British health officials will start offering vaccines to some men who have sex with men and are at the highest risk of catching monkeypox, in an effort to ... Read more »

Deborah James shares ‘proud’ update after huge victory in bowel cancer campaign as Davina McCall hails ‘miraculous’ pal

DAME Deborah James said she feels “so proud” to partner with Tesco in a bowel cancer awareness campaign. The Sun writer, 40, also urged followers to see a GP if ... Read more »

Curiosity has discovered ancient rocks formed by water on Mars

Mars was not always the rocky, lifeless planet that we know it to be now. At least, all of the science seems to point towards that truth. For years, NASA ... Read more »

A groundbreaking solution could help unleash our hydrogen future

Hydrogen gas can be burned as a fuel, with oxygen, leaving only water behind as a by-product. Usable in regular combustion engines, hydrogen fuel itself can be easily produced through ... Read more »

Tony Morley

Tony Morley is a progress studies writer and communicator, specializing in the historical trends in global living standards and the economic, social, political, scientific, and technological forces that drive human ... Read more »

Modified Pfizer Omicron-Based Vaccine Boosts Defense Against Variant? FDA To Discuss Tweaked COVID-19 Medicine

Modified Pfizer Omicron-based COVID-19 vaccine is claimed to boost the defense of the human body against the contagious variant. (Photo : Photo by JOEL SAGET/AFP via Getty Images)This illustration picture ... Read more »

Astronomers Combine the Power of 64 Telescopes To Observe the Structure of the Universe

South Africa’s MeerKAT telescope. Credit: South African Radio Astronomy Observatory (SARAO) An international team of astronomers has combined the power of 64 radio telescope dishes for the first time to ... Read more »

Climate damage caused by growing space tourism needs urgent mitigation

Credit: CC0 Public Domain Published today in the journal Earth’s Future, researchers from UCL, the University of Cambridge and Massachusetts Institute of Technology (MIT) used a 3D model to explore ... Read more »

Paul McCartney's battle with depression after Beatles split left him unable to get up

Paul McCartney had mega-success in his Beatles heyday, but many would be surprised to know how he and his bandmates suffered mentally both during the height of their fame and ... Read more »

Warning polio outbreak may now have spread in UK as experts fear it is passing undetected

POLIO is feared to have now spread across the UK undetected, experts have warned. And a failure to monitor sewage systems will leave communities at risk of the virus spreading ... Read more »