Week 6 NFL picks, odds, 2021 best bets from proven model: This five-way football parlay would pay out 25-1

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Jan 19, 2020; Santa Clara, California, USA; San Francisco 49ers defensive end Nick Bosa (97) celebrates after a sack of Green Bay Packers quarterback Aaron Rodgers (not pictured) in the first half of the NFC Championship Game at Levi’s Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

The Green Bay Packers and Chicago Bears began their rivalry on Nov. 27, 1921. On Sunday, nearly 100 years later, they’ll play for the 203rd time with first place in the NFC North standings on the line. Aaron Rodgers is 20-5 against Chicago in his career and has thrown just 10 interceptions in those starts, while Bears quarterbacks have combined for 39 picks. It comes as no surprise that the Packers are six-point road favorites in the latest NFL odds from Caesars Sportsbook in the latest NFL odds. Which team should you back with your NFL bets and NFL parlays?

Also on Sunday, the undefeated Cardinals visit Cleveland to take on the Browns, and the line is holding steady at Cleveland -3.5 despite news on Friday that Browns running back Nick Chubb (calf) won’t play. Who should you back in those two crucial battles, and which other Week 6 NFL lines should you target as you make your picks? Before making any Week 6 NFL picks or predictions, you need to check out the NFL best bets from the proven computer model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,900 for $100 players on top-rated NFL picks since its inception six-plus years ago. It went a sizzling 24-14 on top-rated NFL picks last season, returning more than $800. The model also enters Week 6 of the 2021 season on an incredible 125-83 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past five years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has locked in five confident NFL best bets for Week 6. If you successfully parlay its picks, you’d be looking at a massive payout of 25-1. You can only see the model’s Week 6 NFL picks at SportsLine. 

Top Week 6 NFL picks

After simulating every NFL game 10,000 times, the model likes New England to cover as a four-point home underdog against Dallas. The Cowboys’ only misstep came on the road in Week 1 against the defending Super Bowl champion Buccaneers. Their offense has looked dominant in every sense, but this is a spot where Patriots head coach Bill Belichick has been extremely reliable.

Since the turn of the century, the Patriots have only been home underdogs 15 times, and Belichick’s boys are a superb 13-2 against the spread during that span. That includes a cover that could have been an outright win just two weeks ago, as Tom Brady returned to Foxborough with the Buccaneers as 6.5-point favorites.

This game will have the national CBS audience with Jim Nantz and Tony Romo on the call, and the model sees the Cowboys coming back down to Earth after covering in their first five games. The model predicts that the Patriots put up more than 350 yards of total offense as New England covers in well over 50 percent of simulations.

How to make Week 6 NFL parlays

The model also jumped on four other matchups where it says the line is way off, including a divisional battle and a game between two playoff teams from a season ago. You can only see the model’s NFL Week 6 best bets at SportsLine. 

What are the model’s top Week 6 NFL picks? And which other matchups should you target for an epic 25-1 payout? Visit SportsLine now to see the Week 6 NFL best bets from a model on a 125-83 run on its top-rated picks, and find out.

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