Waiting list registrations and liver transplants linked to alcoholic hepatitis surge during COVID-19 pandemic

Asia's Tech News Daily

Waiting list registrations and liver transplants linked to alcoholic hepatitis have increased significantly during the COVID-19 pandemic, according to researchers. 

In a recent study from the University of Michigan published Tuesday in the journal JAMA Open Network, authors examined national changes in waiting list registration and liver transplants for alcohol-associated liver disease, as well as the association with the pandemic-linked rise in alcohol sales


Looking at data obtained from the United Network for Organ Sharing Standard Transplant Analysis and Research file for new waiting list registrations and primary deceased donor liver transplants for U.S. adults between Jan. 1, 2016, and Jan. 31, 2021, the team assessed a total of 51,488 new waiting list registrations and 32,320 deceased donor liver transplants.

Pre-COVID-19 waiting list registrants and liver transplant recipients were 50 to 64 years old, with an average age of 58. 

The median ages for both new waiting list registrants during COVID-19 and transplant recipients during COVID-19 was also 58.

Among the new waiting list registrants, more than 36% were women and nearly 64% were men during the pre-COVID-19 period, whereas more than 37% were women and almost 63% were men during the pandemic.

The patients’ data were categorized primary listing diagnosis as alcoholic hepatitis, alcohol-related cirrhosis or any other diagnosis.

The researchers compared proportions of waiting list registrations and deceased donor liver transplants during COVID-19 to the same time frame pre-COVID-19, using χ2 tests to help characterize short-term changes. 

To evaluate those changes, the group compared observed monthly volumes of waiting list registrations and deceased donor liver transplants from March 2020 to January 2021 with forecasted values based on pre–COVID-19 trends.

In addition, national monthly retail alcohol sales from January 2016 to January 2021 from beer, wine and liquor stores were obtained via the U.S. Census Bureau Monthly Retail Trade Report. 

The associations of alcohol sales, waiting list registrations and deceased donor liver transplants were evaluated using a Spearman’s rank-order correlation and analyses were performed using StataCorp statistical software. 


The data was analyzed from March to April of this year.

From June to January 2021, registrations for the national organ transplant waiting list related to alcoholic hepatitis and the number of deceased donor liver transplants have been higher than predicted volumes by more than 50%.

From March 2020 to January 2021, the researchers said there was a “significant increase in the proportions of waiting list registrations” and deceased donor liver transplants for alcoholic hepatitis compared with the same pre-COVID period.

Alternatively, there was an overall reduction in waiting list registration and deceased donor liver transplants at the beginning of the pandemic, as COVID-19 patients overflowed hospitals.

Lastly, the group found that there was a temporal association and positive correlation between increasing waiting list registrations and deceased donor liver transplants for alcoholic hepatitis and increasing retail alcohol sales.

Trends for alcohol-related cirrhosis or any other diagnosis were unchanged. 

“While we cannot confirm causality, this disproportionate increase in association with increasing alcohol sales may indicate a relationship with known increases in alcohol misuse during COVID-19, the authors wrote, adding that because fewer than 6% of patients with severe alcoholic hepatitis are listed for transplantation, the increasing waiting list volume during COVID-19 represents a small fraction of the increase in alcoholic hepatitis.

“This study provides evidence for an alarming increase in [alcoholic hepatitis] associated with increasing alcohol misuse during COVID-19 and highlights the need for public health interventions around excessive alcohol consumption,” they concluded.

“While we cannot confirm causality, this study provides evidence for an alarming increase in alcoholic hepatitis associated with known increases in alcohol misuse during COVID-19,” Maia S. Anderson, a general surgery resident at Michigan Medicine and the first author of the study, said in a statement. “And it highlights the need for public health interventions around excessive alcohol consumption.”

According to John’s Hopkins Medicine, alcoholic hepatitis is inflammation of the liver that leads to liver cell damage and cell death. It is caused by drinking too much alcohol and usually develops over time – though sometimes severe hepatitis can develop suddenly and quickly lead to liver failure and death.

Dietary guidelines from the U.S. Centers for Disease Control and Prevention (CDC) recommend no more than one drink a day for women and two for men.

Excessive alcohol use is responsible for 95,000 deaths in the United States each year, the agency says, including 1 in 10 total deaths among working-age adults.

Internet Explorer Channel Network
Asia's Tech News Daily
News Related


S.Africa's Aspen signs non-binding agreement with J&J for COVID vaccine license

FILE PHOTO: People wearing face masks walk past a logo of South African pharmaceuticals company Aspen Pharmacare at its Johnson & Johnson COVID-19 vaccine facility in Gqeberha, South Africa JOHANNESBURG ... Read more »

Becton confident its COVID-19 tests will detect Omicron variant

(Reuters) –Becton Dickinson and Co said on Tuesday it was confident that its COVID-19 tests would be able to detect the new coronavirus variant Omicron. The company sells a variety ... Read more »

Peoria jury awards woman's family millions in a fatal 2017 milk truck crash

PEORIA — The family of a Stark County woman killed in a 2017 vehicle crash has been awarded $7 million by a Peoria County jury. On Nov. 18, jurors handed ... Read more »

The best panettones for Christmas 2021, tried and tested

© Alamy best panettones christmas 2021 supermarket taste test – Alamy The gloriously festive sweet bread from Milan has conquered the world, becoming a Christmas tradition on almost every continent. ... Read more »

Omicron variant sees surge in vaccinations - over 100 000 people get their first Covid-19 jab

© Provided by Mercury Durban: South Africans appear to have taken heed of President Cyril Ramphosa’s call to vaccinate, as over 100 000 people in South Africa received the Covid-19 ... Read more »

Why it's time to rethink mulled wine

© Getty Images Whether you’re making your own or playing with spices, these supermarket mulled wines make the perfect base – Getty Images Ah, the joys of a steaming tumbler ... Read more »

How to get one of Costa's one million free drinks in December

© Costa is giving away one million free drinks in December – how to get one (Photo: Shutterstock) Costa Coffee is rewarding members of its loyalty scheme with one million ... Read more »

Auto executives expect EVs will own half of U.S., China markets by 2030 - survey

FILE PHOTO: A computer science professor’s electric car is plugged in in her garage in Irvine, California By Joseph White DETROIT (Reuters) – Auto industry executives expect electric vehicles will ... Read more »

Walmart said she shoplifted; jury awards her $2.1 million

MOBILE, Ala. (AP) — An Alabama woman who says she was falsely arrested for shoplifting at a Walmart and then threatened by the company after her case was dismissed has ... Read more »

Authorities search Marilyn Manson's home amid allegations of physical, sexual abuse

LOS ANGELES — Authorities searched the home of rocker Marilyn Manson on Monday after allegations of physical and sexual abuse by several women. Los Angeles County sheriff’s Deputy Eva Jimenez ... Read more »

What year is it? Here's why everyone is talking about Microsoft stock again

Microsoft (NASDAQ: MSFT) recently became a hot topic after CEO Satya Nadella sold more than half of his shares for about $285 million on Nov. 22 and 23. According to ... Read more »

'Squid Game' celebrated at Gotham Awards

Speaking at the Gotham Awards where the Netflix show won two gongs, “Squid Game” star Jung HoYeon said she’s “flustered but happy and grateful” with her newfound success. (Nov. 30) Read more »

‘See, absorb, identify, accept it': Manage anxiety with the ‘3-3-3 rule'

© Provided by The Indian Express While we all keep our physical health in check, we often forget about taking good care of our mental well-being. Mental health issues such ... Read more »

Season's EATINGS! Chef constructs the ultimate Christmas pie

© Provided by Daily Mail MailOnline logo A master baker has built the ultimate Christmas dinner with all the trimmings – stuffed neatly inside a convenient festive pie.   Gareth Mason’s ... Read more »

I'm an obstetrician and this is what I tell ALL my pregnant patients

HAVING a baby can produce a whirlwind of emotions and can be tough for everyone involved. The coronavirus pandemic has been difficult for many pregnant women, with worries of infection ... Read more »

How sitting for hours each day is putting you at risk of silent killer you probably haven't heard of

SITTING for hours each day may be putting you at risk of a silent killer you’ve probably never even heard of. It can affect people of all ages, regardless of ... Read more »

UPDATE 1-Moderna CEO says vaccines likely less effective against Omicron - FT

* Drugmaker CEO warns of “material drop” in vaccine effectiveness * Mutations mean existing vaccines likely need modifying – CEO * Financial markets drop (Adds background) SYDNEY, Nov 30 (Reuters) ... Read more »

Is President Joe Biden doing a good job? Let's talk about it.

The USA TODAY Editorial Board decided to bring in expert voices from the left and right to assess President Biden’s performance. The idea is to start a conversation about whether ... Read more »

'I can't even afford to buy a cart of groceries': Spiraling inflation leaves some grocery workers struggling

The gap between hourly wages and the cost of food means many grocery workers often face the daily experience of being around food they can’t afford. Read more »

Omicron already playing havoc with travel and tourism

The latest Covid-19 variant has introduced new concerns and restrictions into travel plans. Read more »

Founder's daughter named chair of fashion giant Inditex

1 / 2Spain InditexFILE – Marta Ortega daughter of Inditex chief Amancio Ortega, Europe’s richest man, and her husband Sergio Alvarez talk during the Madrid Open tennis tournament in Madrid, ... Read more »

Stewart, Gyllenhaal, more celebrated at Gotham Awards

Hollywood stars including Maggie Gyllenhaal, Tessa Thompson and Nicolas Cage talk film at the prestigious Gotham Awards in New York, where Kristen Stewart won Performer Tribute for playing Princess Diana ... Read more »

ShowBiz Minute: Abloh, Smollett, Rihanna

Virgil Abloh’s creativity celebrated at The Fashion Awards in London; Prosecutors to begin case against Jussie Smollett in Chicago; Rihanna named a national hero in Barbados. (Nov. 30) Read more »

Gunpoint carjacking at Cromwell gas station

A robber stole a car at gunpoint Monday night at a Cromwell gas station, police say. No one was injured during the carjacking, which happened about 9:20 p.m. at the ... Read more »

OPD investigating Monday shooting

Nov. 30—The Owensboro Police Department is investigating a Monday shooting in the 700 block of Elm Street. The shooting was reported at 5:43 p.m. Officer Andrew Boggess, public information officer ... Read more »

Two Israeli doctors infected with Omicron, hospital says

JERUSALEM (Reuters) – The new coronavirus variant, Omicron, has been detected in two Israeli doctors, one of whom had returned from a conference in London in the past week, a ... Read more »

Ex-Vanderbilt kicker Sarah Fuller couldn't cash in during historic run. Now she helps others with NIL

A year ago, Sarah Fuller had the world’s attention and fielded hundreds of promotional offers. She attended the ESPYs, introduced Vice President Kamala Harris during an inauguration TV event and ... Read more »

Michigan football coach Jim Harbaugh to donate bonuses to athletic department employees

Michigan football coach Jim Harbaugh received a $500,000 bonus when his team defeated Ohio State to secure the Big Ten East crown on Saturday, and within 48 hours he’d teamed ... Read more »

Barbados bids farewell to British monarchy, becomes republic

The Associated PressBarbados’ new President Sandra Mason, center right, awards Prince Charles with the Order of Freedom of Barbados during the presidential inauguration ceremony in Bridgetown, Barbados on Tuesday Nov. ... Read more »

Pop-up booster jab centres and round-the-clock vaccines – Boris Johnson's plan to save Xmas

BORIS Johnson will today unveil a major ramping up of the booster rollout to dramatically increase the weekly rate of jabs going into arms. The PM is poised to set ... Read more »

EMA chief says EU is ready to deal with new omicron variant

1 / 4Virus Outbreak Belgium EMAExecutive Director of the European Medicines Agency (EMA) Emer Cooke speaks during an Environment, Public Health and Food Safety (ENVI) Committee at the European parliament ... Read more »

West Newbury man ordered to apologize to police, firefighters

Nov. 30—WEST NEWBURY — A man charged with burning his ex-girlfriend's $70,000 Audi last year was ordered Monday to write apology letters to a state trooper and local firefighters after ... Read more »

Australia to raise possibility of more legislation on tech giants with new inquiry

FILE PHOTO: Facebook‘s new rebrand logo Meta is displayed behind a smartphone with the Facebook logo in this illustration picture By Colin Packham CANBERRA (Reuters) – Australia's Prime Minister Scott ... Read more »

4 found dead at home in Indiana after report of shots fired

FORT WAYNE, Ind. (AP) — The bodies of four people were found at a home in northeastern Indiana following a report of shots being fired, authorities said. Law enforcement responded ... Read more »

D.C.'s violence interruption program to expand

The violence interruption program Cure the Streets will expand next year to four D.C. neighborhood areas to address gun violence. Driving the news: D.C. Attorney General Karl Racine yesterday announced ... Read more »

Uganda launches joint strikes in Congo against ADF rebels

DAKAR, Senegal (AP) — Uganda’s army has launched joint air and artillery strikes against the Allied Democratic Forces rebel group in eastern Congo. The attacks were carried out with Congo’s ... Read more »

Regeneron says COVID-19 drug could be less effective against Omicron variant

FILE PHOTO: FILE PHOTO: The Regeneron Pharmaceuticals company logo is seen on a building at the company’s Westchester campus in Tarrytown (Reuters) -Regeneron Pharmaceuticals Inc said on Tuesday prior analyses ... Read more »

Lamb Keema Shepherd's Pie

© Alex Luck Gently spiced and deeply comforting, this is a delicious hybrid of two classic dishes Add any other vegetables you have to the mince if you want to ... Read more »

Bucks MVP Giannis Antetokounmpo is changing his game, and his body may thank him for it

There is always a collective gasp when all 242 pounds and nearly 84 inches of Giannis Antetokounmpo goes crashing to the hardwood on any given night. Because invariably, it’s due ... Read more »

MLB non-tender deadline candidates: Will sluggers Luke Voit (Yankees), Adam Duvall (Braves) return?

Major League Baseball’s deadline to tender contracts to arbitration-eligible players is Tuesday at 8 p.m. ET, with players who are non-tendered immediately becoming free agents. Players who are tendered a ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic