This COVID vaccine can be inhaled and its being made and tested in Canada

Canadian scientists are set to start testing an inhaled COVID-19 vaccine in humans that targets not only the ever-mutating spike protein the pandemic virus uses to grab onto human cells, but two others that aren’t nearly so prone to mutations.

This COVID vaccine can be inhaled and its being made and tested in Canada
© Provided by National Post Fiona Smaill and research coordinator Emilio Aguirre demonstrate the use of the nebulizer with a volunteer.

Instead of being injected into the deltoid muscles in the arm, the McMaster University vaccine is delivered via tiny aerosol particles breathed deep into the lungs.

The vaccine is part of a second generation of COVID-19 vaccines and one of two Canadian-made formulas that hope to offer a more robust, and more stable immune response. On Tuesday, Quebec-based Medicago Inc. is due to report results from its Phase 3 trial of its plant-based vaccine that involved some 24,000 people, the last step of testing before possible approval.

The McMaster team’s vaccine is being trialed as a booster for people who have received two doses of an mRNA vaccine, such as Pfizer-BioNTech or Moderna. The original idea, early in the vaccine race, was to offer it as a standalone, “but as time has gone on, virtually everybody has now had the opportunity to get an mRNA vaccine,” said Fiona Smaill, a professor of pathology and molecular medicine at McMaster who is leading the human trial.

But with SARS-CoV-2 set to linger for months, perhaps years, and more booster doses likely to follow, it’s still important to test new vaccines that work in different ways, Smaill said.

A potential godsend for the needle phobic, McMaster’s formula is administered through a jet nebulizer that generates a fine, misty solution, “with particles that are so tiny they’re breathed right down deep into the lung,” Smaill said. The delivery route is built on two decades of research on a tuberculosis vaccine led by McMaster professor Zhou Xing.

  • Matt Gurney: Omicron is a test, and Ottawa is failing once again
  • Do we dare hope COVID-19 is becoming milder with Omicron? ‘Hope isn’t science’

Once inside the lungs, the vaccine is designed to deliver a local “mucosal” response, right at the site where the virus enters the body. The aim is a broader type of immune response than can be achieved just by injecting into the muscles of the upper arm, including a more potent T cell response, the researchers said. T cells find and destroy infected cells.

The vaccine uses strains of a weakened adenovirus, a family of viruses that cause the common cold. Two are being tested on 30 healthy volunteers — a vaccine using a human adenovirus, the other a chimpanzee adenovirus.

In addition to the spike protein that peppers the outside of SARS-CoV-2 and that the virus uses to slip inside human cells, the vaccine targets two cellular proteins inside the virus that it needs to grow and spread. “Mutations would be rarely seen in those proteins,” Smaill said.

“If you can generate that local immune response in the lung,” it may prove better to boost with an inhaled vaccine, she said. Canada has also shown that mixing vaccines can trigger a stronger response. “For a number of reasons, this has the promise of being a more effective way to boost,” Smaill said.

This COVID vaccine can be inhaled and its being made and tested in Canada
© Georgia Kirkos The vaccine draws on years of research from Zhou Xing, co-principal investigator and professor in the Department of Medicine.

Still, human trials are just beginning. Medicago has been submitting data to Health Canada as part of a rolling submission. The federal government has a contract to purchase 20 million doses. Medicago is also planning a study early in 2022 testing its vaccine as a booster.

Omicron has “supercharged ” the issue of boosters. If early anecdotal reports suggesting Omicron causes milder infections pan out, “I think we’re going to be okay,” Smaill said. But until more data are available, “we’re all guessing what’s actually going to happen.”

“We seem to be doing better, this time around, than we were a year ago. We’ve got vaccines. We’ve got an understanding of what the major risks are in terms of transmission. So we’ve made progress. How do we keep on, without ever going back? I think that’s really what I’m looking for.”

• Email: skirkey@postmedia.com | Twitter: sharon_kirkey

News Related

OTHER NEWS

Ivan Toney apologises for ‘unacceptable language' used about Brentford in video

Brentford striker Ivan Toney has apologised after a video of him saying “f*** Brentford” was published on social media. The Bees launched an investigation after the video emerged of Toney, ... Read more »

Wolves could land perfect Traore replacement in “exceptional” £27m-rated "phenomenon" - opinion

© Provided by Football FanCast dembele Now that Wolves look set to say goodbye to winger Adama Traore with an initial loan move to Barcelona this month followed by a ... Read more »

'Better late than never': Padma Shri for 102-year-old Gandhian Shakuntala Chowdhary

The Padma Shri might have come quite late to Assam’s 102-year-old Gandhian Shakuntala Chowdhary, but for her family and well-wishers, it is “better late than never”, and they have urged ... Read more »

Ireland: Jack Carty all smiles as he looks to take Six Nations in his stride

Ireland and Connacht fly-half Jack Carty has revealed he is feeling a lot less pressure on his game as he approaches the upcoming Six Nations. © PA Images Ireland: Connacht ... Read more »

Gambia vs Cameroon live stream: How can I watch AFCON quarter-final live on TV in UK today?

© AFP via Getty Images VincentAboubakar2801 The Gambia will look to continue their stunning Africa Cup of Nations debut by pulling off what would be the mother of all shocks. ... Read more »

Monica Galetti offers tips for Queen Elizabeth pudding competition

© Bang Showbiz Queen Elizabeth celebrates her Platinum Jubilee this year Monica Galetti has warned entrants wanting to create a pudding for Queen Elizabeth not to make anything “too crazy”. ... Read more »

Kate Garraway called out for being unable to say Good Morning Britain guest's name

© ITV Screenshot 2021-12-24 at 11.00.08.png Kate Garraway has been criticised by viewers of Good Morning Britain over her inability to pronounce the name of guest, Dr Shola Mos-Shogbamimu. After ... Read more »

Critics call for new rules for online fundraisers after protest convoy takes anonymous donations

© Justin Tang/The Canadian Press Trucks participating in a cross-country convoy protesting measures taken by authorities to curb the spread of COVID-19 park on Wellington Street in front of Parliament ... Read more »

(KEMAS KINI) Izhar ADUN kedua Bersatu keluar parti

© Provided by Free Malaysia Today Izhar Ahmad berkata Bersatu sudah hilang hala tuju dan dilihat gagal. JOHOR BAHRU: Penyandang DUN Larkin, Mohd Izhar Ahmad, mengumumkan keluar Bersatu berkuatkuasa serta-merta. ... Read more »

Quebec's Muslim community to honour victims on 5th anniversary of deadly mosque attack

© CBC Commemorative events marking the fifth anniversary of the Quebec City mosque attack are ending on Saturday. The six men who died in the mass shooting are, clockwise from ... Read more »

Protesters urged to behave as convoy rolls into Ottawa

© Justin Tang/The Canadian Press Trucks participating in a cross-country convoy protesting measures taken by authorities to curb the spread of COVID-19 are parked on Wellington Street in front of ... Read more »

Call for retired teachers to join supply register

© BBC There are 120 supply teachers registered to support the island’s schools Retired teachers on the Isle of Man have been called upon by the education minister to join ... Read more »

France won't stay in Mali if price is too high -defence minister

© Reuters/STEPHANE MAHE FILE PHOTO: European Union countries’ Defence Ministers meet in Brest PARIS (Reuters) – European states combating Islamist militants in Mali will try to find a way to ... Read more »

Rejected by New Zealand, reporter turns to Taliban for help

© Provided by Associated Press FILE – A street vendor selling Taliban flags waits for customers outside an embassy compound in Kabul, Afghanistan, Saturday, Sept. 11, 2021. A pregnant New ... Read more »

Should you buy an iPhone 11 in 2022? It's actually a fair question

It’s 2022. That means, since the iPhone 11 debuted in 2019, we’ve already seen the iPhone 13 and iPhone 12. (We’ve even on the lookout for the iPhone 14 and iPhone SE ... Read more »

Scott Fearon's tips to spot doomed companies ideal for shorting

Prominent hedge fund manager Scott Fearon says investors can find trading opportunities in the most unexpected places which can help them in amassing spectacular long term returns. According to Fearon, ... Read more »

Cracks are finally showing in retail traders' 'diamond hands', after 2 years of relentless tech-stock dip buying

© VIEW press/Getty Images Data suggests retail investors are pivoting away from flashy tech stocks. VIEW press/Getty Images Retail investors seem to be tiring of buying the dip in flashy ... Read more »

Martyn Ford vows to settle rivalry with "disgusting" and "useless" Iranian Hulk

Strongman Martyn Ford has vowed to finally settle his rivalry with “useless” rival Iranian Hulk. The British star will face bitter rival Sajad Gharibi who is branded as the ‘Iranian ... Read more »

Kourtney Kardashian accused of editing snap with larger-than usual bum

Reality TV star Kourtney Kardashian has joined sister Kim in being accused of a “Photoshop fail due” to a recent post on Instagram. The 42 year old reality TV star ... Read more »

Norwich stabbing: Man and woman arrested after teenager killed

© PA Archive Police are appealing for witnesses or anyone with information to come forward – PA Two people have been arrested after a teenager was stabbed to death in ... Read more »

Karl Toko-Ekambi: Lyon star helping power Cameroon surge

© Kenzo Tribouillard, AFP Lyon striker Karl Toko-Ekambi has been crucial to Africa Cup of Nations hosts Cameroon winning the status of favourites after surging through the tournament so far. His ... Read more »

Tennis-Nadal meets dream-wrecker Medvedev in more than just a Slam final

© Reuters/TOBY MELVILLE ATP Finals By Sudipto Ganguly MELBOURNE (Reuters) – Rafa Nadal and Daniil Medvedev will face off in a generational clash on Sunday for the year’s first Grand ... Read more »

“A very fast-moving situation”: Journalist drops big Burnley transfer claim

© GiveMeSport Burnley manager Sean Dyche in Premier League action Burnley‘s ongoing search for a new striker following the shock departure of Chris Wood is a ‘very fast-moving situation,’ according ... Read more »

Storm Malik: Met Office issues severe weather warning for Scotland and northern England

© Getty Images Huge waves hitting the UK during Storm Arwen in November – Getty Images The UK will be “dealt a glancing blow” by a Danish storm this weekend, ... Read more »

Why India observes Martyr's Day on January 30 - Know here

© Provided by DNA Martyrs’ Day, also known as ‘Shaheed Divas’, is celebrated every year on January 30 to mark the death anniversary of Mahatma Gandhi.   India celebrates ‘Shaheed ... Read more »

Covid-19 in Maharashtra: Pune schools and colleges to reopen from February 1, says Dy CM Ajit Pawar

© Provided by DNA As Covid-19 cases in Maharashtra continue to decline, the state’s Deputy Chief Minister Ajit Pawar, on Saturday, announced that schools and colleges in Pune city are ... Read more »

Tiada kerjasama tanpa DAP, tegas Anwar

© Provided by Free Malaysia Today PH tidak akan menerima cadangan kerjasama dengan PN bagi menghadapi menghadapi PRN Johor tanpa DAP, kata Anwar Ibrahim. (Gambar Bernama) PETALING JAYA: Pakatan Harapan ... Read more »

Punjab Assembly Polls: AAP's CM candidate Bhagwant Mann files nomination from Dhuri

© Provided by Zee News Dhuri: AAP’s chief ministerial face Bhagwant Mann on Saturday (January 29) filed his nomination papers from the Dhuri assembly seat for the upcoming assembly elections ... Read more »

Heather Knight joins Rachel Helyoe-Flint in exclusive club

168* – Heather Knight‘s unbeaten score in the first innings is the highest individual score by a visiting batter in Australia in Women’s Tests. Smriti Mandhana’s 127 during the Pink-ball ... Read more »

Police bust gang involved in phishing scams in Telangana, 9 arrested from Jharkhand

Police busts gang involved in phishing scams in Telangana, 9 arrested from Jharkhand Rachakonda police of Hyderabad busted a gang involved in cyber fraud and were operating from Dhanbad, Jharkhand. ... Read more »

Queen Elizabeth news latest – Scandalous letter reveals her father ‘had affair' & Charles ‘terrified' of becoming King

AN UNEARTHED letter written by Edward VIII, who famously abdicated the throne in 1936, reveals how he lured Lady Sheila Loughborough's husband away so his brother George VI could be ... Read more »

Three terror associates arrested in Jammu and Kashmir; grenades and pistols recovered

© Provided by Zee News New Delhi: The Jammu and Kashmir Police on Friday (January 28) busted a terror module and held three terrorist associates of The Resistance Front (TRF), ... Read more »

Ivan Toney apologises to Brentford fans over X-rated video of striker attacking club as Bees chiefs launch probe

IVAN TONEY has apologised to fans after a video emerged online showing him saying: “F*** Brentford.” Furious Bees fans demanded the club punish their star striker over the video, which ... Read more »

Virginia Roberts ‘will accept settlement if Andrew is held to account' says lawyer as he slams ‘victim-shaming' Duke

PRINCE Andrew accuser Virginia Roberts will “accept a settlement if the Prince is held to account,” her lawyer has claimed. US attorney David Boies has slammed “victim shaming” Duke after ... Read more »

Prince Harry & Meghan Markle ‘asked for secret talks' with Spiderman couple Tom Holland & Zendaya despite never meeting

PRINCE Harry and Meghan Markle asked for secret talks with Spider-Man couple Tom Holland and Zendaya despite them never meeting, a source has claimed. The Duke and Duchess were eager ... Read more »

Strictly Come Dancing's Nadiya Bychkova and Kai Widdrington caught snogging in picture that proves they are an item

STRICTLY lovers Nadiya Bychkova and Kai Widdrington were seen snogging in a hotel just ten days after insisting they were not an item. The couple’s very public display of affection ... Read more »

Two Michigan colleges mistakenly award scholarships to students

Oakland University erroneously notified students that they would receive top tuition awards, just days after Michigan State University mistakenly awarded full-ride scholarships to students. AP A university in Michigan said ... Read more »

Pokwang displays dramatic prowess in her second Magpakailanman episode

© Provided by PEP.ph Muling mapapanood si Pokwang sa isang fresh episode ng Kapuso drama anthology na Magpakailanman ngayong Sabado ng gabi, January 29, 2022, sa GMA-7. Ito ang ikalawang pagkakataong gumanap ... Read more »

What do Charms do in Pokémon Legends: Arceus?

© Provided by GamePur Charms are one of the ways you can adjust your gameplay slightly. They assist you while you are out in the wilds of Hisui by aiding ... Read more »

FCZ-Boss Canepa über Grinta, Coach Breitenreiter und seine Ära

© KEYSTONE/ANTHONY ANEX Müde ist Ancillo Canepa auch nach 15 Jahren als Präsident des FC Zürich keinesfalls. Er sprüht beim Interview mit der Nachrichtenagentur Keystone-SDA vor Enthusiasmus. Beim Gespräch in ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic