The Indianapolis Colts seek their first win in three tries against an NFC West opponent this season when they take on the host San Francisco 49ers on Sunday Night Football. The Colts (2-4), who opened the season with back-to-back losses to the Seahawks and Rams, have won two of their past three games. The 49ers (2-3), who have lost three in a row, are playing their first AFC opponent this season. San Francisco was 2-2 against the AFC in 2020.
The game from Levi’s Stadium in Santa Clara, Calif., is scheduled to begin at 8:20 p.m. ET. The 49ers are averaging 23.4 points per game, while the Colts average 23.2. San Francisco is a 3.5-point favorite in the latest Colts vs. 49ers odds from Caesars Sportsbook, while the over-under for total points scored is set at 42. Before you make your 49ers vs. Colts picks or any other Sunday Night Football predictions, you need to see what SportsLine’s Tom Fornelli has to say.
The CBS national writer went a profitable 31-22 last season on his NFL best bets. What’s more, he has demonstrated a particularly sharp eye for the 49ers. In fact, Fornelli has gone a stunning 15-6 on picks involving San Francisco, returning more than $850 to $100 players. Anyone who has followed him is way up.
- 49ers vs. Colts spread: San Francisco -3.5
- 49ers vs. Colts over-under: 42
- 49ers vs. Colts money line: Indianapolis +150, San Francisco -175
- IND: The Colts are 4-2 against the spread this season
- SF: The over is 4-0 in the 49ers’ last four games following an ATS loss
Featured Game| San Francisco 49ers vs. Indianapolis Colts MoneylineSpreadTotal SF -175 BET NOW -3.5+100BET NOW o42-110BET NOW IND +150 BET NOW +3.5-120BET NOW u42-110BET NOW
Why the 49ers can cover
San Francisco has a number of weapons on offense, including fullback Kyle Juszczyk. Although he has just seven carries for 16 yards, he has 14 receptions for 135 yards and one touchdown. He has converted two first downs on the ground and eight through the air. Juszczyk has a receiving touchdown in three of his last five home games.
Also playing well at home is wide receiver Brandon Aiyuk, who has four or more catches in three of his past four games at home. He will be looking for his third game in a row against an AFC opponent with five or more receptions and 90 or more receiving yards. For the season, Aiyuk has eight catches for 90 yards (11.3 average) and one touchdown. He has six first-down conversions.
Why the Colts can cover
After struggling early in the season, Indianapolis has been playing much better of late. Wide receiver Michael Pittman Jr. is a big part of the offense, and leads all Colts receivers with 31 receptions for 403 yards (13 average) and one touchdown. He has five explosive plays and 19 first-down conversions. Pittman has 50 or more receiving yards in four of the past five games. His best game was an eight-catch, 123-yard performance against the Rams in Week 2.
Wide receiver Zach Pascal has also made his presence felt, making 18 receptions for 204 yards (11.3 average) and three touchdowns. He has three explosive plays of 20 or more yards and has converted nine first downs. In the 28-16 season-opening loss to the Seattle Seahawks, Pascal had four receptions for 43 yards and two touchdowns. In four seasons with the Colts, Pascal has appeared in 54 games with 130 receptions for 1,708 yards (13.1 average) and 15 touchdowns.
How to make Colts vs. 49ers picks
For Sunday Night Football, Fornelli is leaning over on the point total, but he also says a critical X-factor makes one side of the spread a must-back. Fornelli is only sharing his 49ers vs. Colts picks at SportsLine.
So who wins Colts vs. 49ers on Sunday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Colts vs. 49ers spread you need to jump on, all from the expert who returned more than $850 to $100 players in the last 21 San Francisco games, and find out.Internet Explorer Channel Network