New Insights Into Retinal Neurons

Summary: Researchers have identified a new type of retinal ganglion cells.

Source: Northwestern University

Northwestern Medicine investigators have identified a new type of retinal ganglion cell, the neurons in the retina that encode the visual environment and transmit information back to the brain, according to a study published in Neuron.

The specific features of this cell, which is called a “bursty suppressed-by-contrast” (bSbC) retinal ganglion cell (RGC), overturn a decades-old assumption about the relationship between the cells’ inputs from photoreceptors and outputs to the brain, according to Gregory Schwartz, Ph.D., the Derrick T. Vail Professor of Ophthalmology and senior author of the study.

“The classic view was that these ganglion cells simply integrate their excitation and inhibition inputs, and that will tell you how the cell responds to visual stimulus,” said Schwartz, who is also a professor of Neuroscience.

“Our findings reveal that these cells have their own intrinsic computation, which has interesting implications for things like retinal prosthetics.”

There are more than 40 types of RGCs which transmit information about specific and complex characteristics of a visual scene, including motion, direction, orientation and color. For example, the “off sustained alpha” (OFFsA) RGC type has a baseline firing rate, but when light increases, the cell’s signaling to the brain decreases and vice versa.

In the study, investigators compared the responses of OFFsA and bSbC ganglion cell types to different visual stimuli, recording the resulting signals that would be sent to the brain. The study authors discovered the bSbC has a curious mechanism: The cell has a baseline rate of signaling towards the brain, but both increases and decreases in light result in decreased signaling, a one-way signaling pattern.

“The signaling can only go down,” Schwartz said.

Further, the investigators tested the classic view of how these ganglion cells integrate inputs. These cells receive excitatory and inhibitory signals from photoreceptors in the retina, and the prevailing theory dictated that these inputs combine to reach some threshold that causes a change in signaling output.

New Insights Into Retinal Neurons

There are more than 40 types of RGCs which transmit information about specific and complex characteristics of a visual scene, including motion, direction, orientation and color. Image is in the public domain

To test this, Schwartz and his collaborators swapped the inputs into the OFFsA and bSbC ganglion cells with one another, finding that the output signaling in this experiment was identical to normal activity.

“This means they have their own ion channels that impact output, their own set of electrical conductances that contribute to the output,” Schwartz said.

The findings have implications for devices such as retinal prosthetics, which aim to stimulate RGCs that are no longer responsive to light. Current prosthetics can only produce crude vision, and Schwartz believes part of the problem is that the prosthetics are sending the wrong signals to the wrong types of cells.

“You can’t turn on the light to check what kind of retinal ganglion cells they are because the receptors are damaged—it’s a catch-22,” Schwartz said.

Instead, investigating the intrinsic computation in each cell type could help scientists identify which cells are which, even without the correct photoreceptor input.

“If you can get detailed information about these onboard computations, you might be able to send each cell type the correct signaling,” Schwartz said.

About this visual neuroscience research news

Author: Will DossSource: Northwestern UniversityContact: Will Doss – Northwestern University
Image: The image is in the public domain

Original Research: Closed access.
“Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types” by Sophia Wienbar et al. Neuron


Differences in spike generation instead of synaptic inputs determine the feature selectivity of two retinal cell types


  • Characterizes the bursty suppressed-by-contrast retinal ganglion cell type in the mouse
  • It goes into depolarization block in response to negative contrast stimuli
  • Depolarization block is from low NaV conductance, shorter AIS, and less NaV1.6


Retinal ganglion cells (RGCs) are the spiking projection neurons of the eye that encode different features of the visual environment.

The circuits providing synaptic input to different RGC types to drive feature selectivity have been studied extensively, but there has been less research aimed at understanding the intrinsic properties and how they impact feature selectivity.

We introduce an RGC type in the mouse, the Bursty Suppressed-by-Contrast (bSbC) RGC, and compared it to the OFF sustained alpha (OFFsA).

Differences in their contrast response functions arose from differences not in synaptic inputs but in their intrinsic properties. Spike generation was the key intrinsic property behind this functional difference; the bSbC RGC undergoes depolarization block while the OFFsA RGC maintains a high spike rate.

Our results demonstrate that differences in intrinsic properties allow these two RGC types to detect and relay distinct features of an identical visual stimulus to the brain.

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White Water Rafting or KayakingMount Fuji Overnight Climb ItinerarySip & Gogh Paint Studio: Unleash Your Inner Van Gogh | LakwatseroBatanes ItineraryHow to Get to Quitinday HillsAbout Callao CaveDiscover LakawonBiking to Taal: A Fun Ride to Batangas’ Heritage TownAntique Blooming: The Rafflesia of San RemigioMalasimbo Lights and Dance FestivalBacolod ItineraryPoon HillAttractions in Mirador Heritage and Eco ParkHulhumale Public BeachRomblon Island: Bonbon Beach, Tiamban Beach & MoreAdventure in Sabah: White Water Rafting in Padas River | LakwatseroHow to Get to Hinakpan Mystical HillsWelcome to Lake SebuAbout CasiguranAbout BuscalanHow to Go to Kalanggaman IslandFaro de Cabo Bojeador (Cape Bojeador Lighthouse)Backpacking Maldives: Budget Itinerary, Expenses & TipsHow to Get ThereOffbeat Bohol Itinerary: 3D/2N of AdventuresHow to Get to Tawi-TawiAlona BeachPangilatan Falls: The Forgotten Gem of Tapaz, CapizWorld War I: SMS Cormoran II3D/2N Taiwan Itinerary: Taipei – Yehliu – ShiffenLaos for Backpackers: Getting There on a BudgetBasic RequirementsHow to Get to Antong FallsCathedral CaveHow to Go to Gubat, SorsogonAbout SadangaHow to Get to Bugui Point LighthouseHow to Get to Cabra Island LighthouseCebu Itinerary: Three-Day Adventures in the SouthAbout AndaLuna: A Day in the Show Window of Apayao | LakwatseroMargues Blue LagoonFinding Palaui’s Cape Engaño Lighthouse | LakwatseroHow to Get to Mantayupan Falls of Barili, CebuHow to Get to MaligcongLinapacan Islands: Between Paradise | LakwatseroKLIA to KLCCHow to Get to JomaligBanaug ShoalEspadang Bato – Payaran Falls Day Hike Itinerary10 Remarkable Philippine Destinations for Solo TravelMiagao Church: A UNESCO World Heritage Site in IloiloAbout Carbin ReefAbout Parola IslandCabra WreckageCobra Falls: Ozamiz City’s Best Kept SecretBasco: The Chapel on the Hill of Tukon | LakwatseroBack in Kathmandu’s Lovely Mess | LakwatseroHimalayan Adventure: Kathmandu to Pokhara Overland | LakwatseroItineraryChinatown Vancouver (Stop #23)Situbo Falls: Tampilisan's Awesome SurpriseHow to Get to Inambakan FallsTuasan Falls: Another Camiguin’s Charmer | LakwatseroHow to Get to Lake SebuMarinduque Loop: Biking in the Heart of the Philippines1. 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