Moderna's vaccine is the most effective, but Pfizer and J&J also protect well, CDC-led study says

A head-to-head study of all three authorized coronavirus vaccines in the United States finds the Moderna vaccine is slightly more effective than Pfizer’s in real-life use in keeping people out of the hospital, and Johnson & Johnson’s Janssen vaccine comes in third, but still provides 71% protection.

© Algi Febri Sugita/SOPA Images/LightRocket/Getty Images DUSUN BAMBU, WEST BANDUNG REGENCY, INDONESIA – 2021/09/15: Vials and a box of the Moderna Covid-19 vaccine seen in Lembang Tourism area. The West Bandung Regency Government collaborating with tourism managers held a mass COVID-19 vaccination in Lembang Tourism area to attract public interest in vaccinations. (Photo by Algi Febri Sugita/SOPA Images/LightRocket via Getty Images)

Pfizer’s vaccine provided 88% protection against hospitalization, and Moderna’s was 93% effective.

The US Centers for Disease Control and Prevention led a nationwide study of vaccination involving more than 3,600 adults hospitalized for Covid-19 between March and August.

“Among U.S. adults without immunocompromising conditions, vaccine effectiveness against COVID-19 hospitalization during March 11- August 15, 2021, was higher for the Moderna vaccine (93%) than the Pfizer-BioNTech vaccine (88%) and the Janssen vaccine (71%),” the team wrote in the CDC’s weekly report on death and disease, the MMWR.

“Although these real-world data suggest some variation in levels of protection by vaccine, all FDA-approved or authorized COVID-19 vaccines provide substantial protection against COVID-19 hospitalization.”

They found that the biggest difference between the vaccine made by Moderna and Pfizer/BioNtech’s vaccine was driven by a decline that started about four months after people were fully vaccinated with Pfizer’s vaccine.

“Differences in vaccine effectiveness between the Moderna and Pfizer-BioNTech vaccine might be due to higher mRNA content in the Moderna vaccine, differences in timing between doses (3 weeks for Pfizer-BioNTech versus 4 weeks for Moderna), or possible differences between groups that received each vaccine that were not accounted for in the analysis,” the team wrote.

“Vaccine effectiveness for the Pfizer-BioNTech vaccine was 91% at 14 -120 days after receipt of the second vaccine dose but declined significantly to 77% at more than 120 days,” the team wrote.

Pfizer’s and Moderna’s vaccines both use genetic material called messenger RNA to deliver immunity, but they use differing doses and slightly different formulations. The Janssen vaccine uses an inactivated common cold virus called adenovirus — a viral vector — to carry genetic instructions into the body.

“A single dose of the Janssen viral vector vaccine had comparatively lower anti-SARS-CoV-2 antibody response and vaccine effectiveness against COVID-19 hospitalizations,” the team said. “Understanding differences in vaccine effectiveness by vaccine product can guide individual choices and policy recommendations regarding vaccine boosters. All FDA-approved or authorized COVID-19 vaccines provide substantial protection against COVID-19 hospitalization.”

CDC worked with researchers across the country to study 3,689 patients at 21 hospitals in 18 states for the study. They also looked at antibodies in the blood of 100 healthy volunteers after they had been vaccinated with one of the three available vaccines.

“These real-world data suggest that the two-dose Moderna and Pfizer-BioNTech mRNA vaccine regimens provide more protection than does the one-dose Janssen viral vector vaccine regimen. Although the Janssen vaccine had lower observed vaccine effectiveness, one dose of Janssen vaccine still reduced risk for COVID-19-associated hospitalization by 71%,” they wrote.

The study had limitations. “This analysis did not consider children, immunocompromised adults, or vaccine effectiveness against COVID-19 that did not result in hospitalization,” the team wrote. Plus, the volunteers were only followed for 29 weeks — just over six months.

Internet Explorer Channel Network
News Related


Manchin raises concerns over billionaires' tax as Democrats scramble to close deal

Democrats on Wednesday scrambled to close the deal on President Joe Biden’s landmark social spending legislation, focusing on new ways to pay for the package, including a billionaires’ tax the ... Read more »

Pelosi sets Rules meeting on Biden agenda; no infrastructure vote in sight

The House Rules Committee will discuss portions of President Biden’s massive social spending package on Thursday, the same day the president is set to head to Europe for a high-stakes ... Read more »

Rebel Wilson Gets Candid About Her 77-Pound Weight Loss and Fertility Struggles

Rebel Wilson, 41, just opened up about her weight loss journey in a new interview. The actress was also honest about her recent fertility struggles. But, Rebel says she’s feeling ... Read more »

Why Working at Facebook Is Like Playing Chess With an Alien, According to Leaked Documents

Over the last several weeks, a cache of internal Facebook documents leaked by whistleblower Frances Haugen has revealed the company knew about—but did little to act on—a range of societal ... Read more »

What to Know About Flu Shots

Since the arrival of the novel coronavirus pandemic, the word “vaccine” has been almost exclusively associated with the shots that have been found highly effective in preventing severe illness and ... Read more »

'Rust' armorer 'mishandled' guns on previous film with Nicolas Cage, crew members say

Two crew members tell CNN that Hannah Reed-Gutierrez, 24, who was the lead armorer on the set of “Rust,” mishandled weapons on a previous film project. © Jae C. Hong/AP ... Read more »

Rebel Wilson On How Her Life Has Changed Since Her 77-Pound Weight Loss

© Provided by Shape Getty Images Rebel Wilson is opening up about her “Year of Health” journey, which she began early last year. The Australian actress recently revealed that she’s ... Read more »

Iran Says its Ready for Nuclear Talks in New Test for Biden's Mideast Policy

Iran will resume nuclear talks “before the end of November,” its chief nuclear negotiator Ali Bagheri Kani announced in a tweet on Wednesday. © Photo by Majid Saeedi/Getty Images Ebrahim ... Read more »

Merck to Allow Other Drugmakers to Produce Lifesaving COVID Pill for Poorer Countries

Pharmaceutical company Merck has agreed to permit other drug manufacturers to produce its potentially lifesaving COVID-19 treatment pill in an effort to curb the numbers of hospitalizations and deaths in ... Read more »

In a Book Full of Must-Make Italian American Recipes, This Is My Favorite

© Photo by Isa Zapata, Food Styling by Cyd McDowell, Prop Styling by Paige Hicks In the fall of 2019, I began testing the recipes for Italian American, the cookbook ... Read more »

Has American Express (AXP) Outpaced Other Finance Stocks This Year?

For those looking to find strong Finance stocks, it is prudent to search for companies in the group that are outperforming their peers. Is American Express (AXP) one of those ... Read more »

How to Chill Pie Dough at the Absolute Last Minute

© Provided by Food52 Thanksgiving is just around the corner. Maybe you’re reading this a few days in advance, the night before, or gulp the morning of. You followed all ... Read more »

Stacey Abrams PAC Wipes Out $212 Million in Medical Debt for 108,000 People in 5 States

A political organization led by Stacey Abrams has paid off medical debts owed by 108,000 people in Georgia, Arizona, Louisiana, Mississippi and Alabama. © NAACP via Getty Images Stacey Abrams’ ... Read more »

That Tainted Halloween Candy Myth Just Won't Go Away

A group of trick-or-treating children attended the Haunted Fountain at the Cathedral, a Halloween event on Oct. 31, 2021 in New York City. (Jutharat Pinyodoonyachet/The New York Times) As children ... Read more »

Report: Patriots signing linebacker Calvin Munson off Dolphins' practice squad

Calvin Munson signed to the Miami Dolphins’ 53-man roster off the New England Patriots’ practice squad in December 2019. The linebacker will now make a return trip. © Photo by ... Read more »

Tua Tagovailoa: I don't not feel wanted by the Dolphins

© Provided by NBC Sports The last two weeks have featured a lot of chatter about the Dolphins potentially making a trade for quarterback Deshaun Watson and that’s left the ... Read more »

Expert NFL Survivor Pool Advice, Tips, Picks Week 8

Last week was yet another mild one in NFL survivor pools, as the biggest upset (Carolina) caused just three percent of pools to be eliminated. This week, there are a ... Read more »

Wish Zendaya Had More Screen Time in Dune? Hear What the Filmmakers Have to Say About the Sequel

Wanted Zendaya to have more screen time in Dune? You’re not alone. After the film was released last week, fans took to social media to express their frustrations that the ... Read more »

This Firm Is Building Villages of Tiny Homes in Response to the Housing Crisis in Los Angeles

© Photo: Lehrer Architects An aerial view of the tiny homes village in Alexandria Park. Nerin Kadribegovic came to America as a refugee in response to the Yugoslav Wars of ... Read more »

Mark Zuckerberg & Priscilla Chan's Former Home Workers Sue Over Alleged Failure to Pay, Harassment

© Provided by People Tim Mosenfelder/Getty (L-R) Priscilla Chan and Mark Zuckerberg Mark Zuckerberg and wife Priscilla Chan have been sued by two former employees who allege that they faced ... Read more »

Low-Key, Innovative Paris Restaurants to Bookmark for Your Next Trip

© Nicolas Lobbestael Few things in life are better than eating your way through Paris, whether you’re a poivre-seasoned veteran or a first-timer trying to pronounce coq au vin. And ... Read more »

Greyhound resuming US–Canada service on Nov. 8

© Provided by The Points Guy MSN has partnered with The Points Guy for our coverage of credit card products. MSN and The Points Guy may receive a commission from ... Read more »

USMNT's Weston McKennie Scores First Goal of the Season for Juventus

© Provided by Sports Illustrated Weston McKennie headed Juventus level with Sassuolo in the 76th minute, but his side wound up conceding at the death to lose 2–1. View the ... Read more »

White House still thinks spending deal could be made before Europe trip

White House press secretary Jen Psaki said Wednesday that it is still possible President Biden could make a deal with congressional Democrats on his economic agenda before he leaves for ... Read more »

Intel CEO Pat Gelsinger says Moore's Law is back

Moore’s Law, the gauge of steady processor progress from Intel co-founder Gordon Moore, has taken a beating in recent years. But it’s making a comeback, Intel Chief Executive Pat Gelsinger ... Read more »

FTC goes after gig economy and multilevel marketers for pandemic exploitation

The Federal Trade Commission is calling out technology firms and gig-based companies such as Amazon and Uber for potentially deceiving or misleading those in financial distress with money-making pitches during ... Read more »

Merrick Garland defends school memo at Senate hearing against GOP criticism, call for resignation

WASHINGTON – Attorney General Merrick Garland defended his memo about assisting local school officials against violence and threats of violence, as Senate Republicans  blasted the memo as “shameful” and “intimidating,” and one ... Read more »

Marjorie Taylor Greene invested as much as $50,000 in the Trump SPAC before its stock plunged

Georgia Rep. Marjorie Taylor Greene bought as much as $50,000 worth of shares in a shell company that is merging with former President Donald Trump’s new media venture, according to ... Read more »

Democrats play a dangerous game branding all Republicans 'extremists'

When your go-to electoral strategy is to accuse all Republicans of being extremists, including even Mitt Romney and now the fleece-sporting centrist Glenn Youngkin, voters eventually tune out the warnings. ... Read more »

Van Jones on his new podcast in partnership with Amazon Music and how he plans to implement a $100 million gift for charity from Jeff Bezos

© Leigh Vogel/Getty Images Van Jones. Leigh Vogel/Getty Images Van Jones spoke to Insider about his new podcast, “Uncommon Ground with Van Jones,” which debuted this week in partnership with ... Read more »

GABBY PETITO: Her father says contents of Laundrie notebook won't bring him closure

NEW YORK (1010 WINS) – Gabby Petito’s father, Joe, said he isn’t obsessing over Brian Laundrie’s recently recovered notebook and that he doesn’t expect its contents to bring him any ... Read more »

Stan Kroenke begins backing away from relocation indemnity agreement

© Provided by NBC Sports St. Louis may be moving closer to a potential expansion team, if it wants one. Earlier this month, we outlined the factors that could result ... Read more »

‘It Has Been a Whirlwind': Kate Scott Is Taking It All in As the Voice of the Sixers

© Provided by Sports Illustrated In September, the broadcaster was the second woman hired as a full-time play-by-play announcer in NBA history when the 76ers added her to their team. ... Read more »

Man City ‘falling behind' Euro giant in race for striker with huge release clause

Reigning Premier League champions Man City are ‘losing ground’ in the race for a Brazilian goalscorer, according to reports. © PA Images Man City target Yuri Alberto celebrates scoring for ... Read more »

Five subs rules to become permanent - pressure on Premier League to adopt it

Five substitutions per game is set to become a permanent rule change, which could put the Premier League under more pressure to adopt it after reverting back to three substitutions. ... Read more »

Guide to life insurance for parents of children with disabilities

Caring for a child with special needs can be both a great joy and a challenge. You want your child to live to their full potential, in whatever form that ... Read more »

Does Medicare Cover Eyeglasses and Contacts?

Original Medicare generally doesn’t pay for eyeglasses or contact lenses. You can obtain some vision care insurance through Medicare Advantage or a private or group plan, but you should assess ... Read more »

How to upgrade the fishing rod in Moonglow Bay

With fishing being the core gameplay mechanic in Moonglow Bay, you’re probably wondering how to upgrade the fishing rod. When selecting a loadout at a fishing spot, you’ll notice multiple ... Read more »
On you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic