Merck strikes deal for global access to Covid drug

Asia's Tech News Daily

Merck strikes deal for global access to Covid drug
© Suhasini Jha Merck strikes deal for global access to Covid drug

US drugmaker Merck & Co. on Wednesday announced a deal that could see generic versions of its medication for Covid sufferers widely distributed in poorer countries, in a first during the pandemic.

The global Medicines Patent Pool (MPP) said it had signed a voluntary licencing agreement with Merck to facilitate affordable worldwide access for its investigational oral Covid-19 antiviral medicine molnupiravir.

Subject to regulatory approval, the deal will help create broad access to molnupiravir in 105 low- and middle-income countries.

The US and European Union medicines regulators are already reviewing the drug.

Antivirals like molnupiravir work by decreasing the ability of a virus to replicate, thereby slowing down the disease.

Given to patients within days of a positive test, the treatment halves the risk of hospitalisation, according to a clinical trial conducted by Merck, also called MSD outside the United States.

The Geneva-based MPP is a United Nations-backed international organisation that works to facilitate the development of medicines for low- and middle-income nations.

Under the deal, Merck grants a licence to the MPP, under which the organisation can then sub-licence to makers of generic drugs.

The deal means the drug’s developers will not receive sales royalties while Covid-19 remains classified as a public health emergency of international concern (PHEIC) by the World Health Organization.

A PHEIC is the highest alarm the WHO can sound and its emergency committee last week reconfirmed the pandemic’s top-alert status.

– Price not yet set –

“The interim results for molnupiravir are compelling and we see this oral treatment candidate as a potentially important tool to help address the current health crisis,” said MPP executive director Charles Gore.

Merck is jointly developing molnupiravir with Ridgeback Biotherapeutics.

The Miami-based company’s chief executive Wendy Holman said the deal meant “quality-assured generic versions of molnupiravir can be developed and distributed quickly following regulatory authorisation”.

The MPP was founded by Unitaid, which works on innovations to prevent, diagnose and treat major diseases in poorer countries.

Molnupiravir prices have not yet been determined, but its simplicity, plus competition among generic manufacturers should mean low prices in the 105 poorer countries, said Unitaid spokesman Herve Verhoosel.

He said in countries with low vaccination rates, millions would need the drug to prevent progression to serious illness.

“We also need to see this licence followed by others as soon as possible for other key promising products expected to come out of the pipeline soon, for which we also need to ensure broad supply and affordability,” Verhoosel added.

– IP waiver call –

While the search for vaccines has resulted in multiple products being approved for emergency use in the pandemic, the hunt for treatments for those who have already caught the disease has not been as fruitful.

The medical charity Doctors Without Borders (MSF) welcomed the announcement but said it did not go far enough.

“The licence excludes key upper-middle-income countries like Brazil and China from its territory, where there is strong, established capacity to produce and supply antiviral medicines,” MSF senior policy advisor Yuanqiong Hu said.

“Furthermore, the licence contains an unacceptable clause undermining the rights to challenge patents on molnupiravir.”

Hu said the agreement underlined the urgent need for a temporary waiver of intellectual property rights for all Covid-19 medicines, vaccines and tests.

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