Inexpensive antidepressant can cut Covid hospitalisation risk, says study

Asia's Tech News Daily

Costing about $4 per 10-day course, fluvoxamine could be a game-changer for low-income countries that have low vaccination rates and lack access to more advanced Covid-19 therapies, scientists say (Getty Images)

Early treatment of Covid-19 patients with the commonly prescribed antidepressant fluvoxamine can cut hospital admissions by up to 30 per cent, and potentially save lives, a new study has suggested.

The inexpensive drug could provide low-cost protection against severe Covid infection or death in low-income countries that are yet to receive adequate doses of vaccines, said the researchers from Brazil, US, Canada and Australia.

In the largest clinical trial of the drug conducted between 15 January and 6 August, 739 randomly selected Brazilian Covid-19 patients were treated with fluvoxamine, while another 733 received a placebo.

The researchers tracked every patient who had received fluvoxamine for 28 days to determine their health and if they still needed hospital treatment. They found that there was up to 30 per cent reduction in hospitalisations among those who had received 100mg of fluvoxamine twice daily for ten days, compared to those who had received the placebo.

This content is not available due to your privacy preferences.Update your settings here to see it.

The drug, commonly used to treat mental health conditions such as depression and obsessive compulsive disorder, was chosen to study its Covid-19 treatment potential due to its anti-inflammatory properties, noted the research, published in The Lancet journal.

Fluvoxamine was offered to patients in one of the arms of the “Together Trial” — a randomised adaptive platform trial to investigate the efficacy of eight repurposed treatments for Covid-19 among high-risk adult outpatients.

Of the 741 patients who received fluvoxamine, the scientists found that 79 required an extended stay for more than six hours in an emergency setting or hospitalisation, compared to 119 out of the 756 participants who received a placebo.

Costing about $4 per 10-day course, fluvoxamine could be a game-changer for low-income countries that have low vaccination rates and lack access to more advanced Covid-19 therapies, scientists said.

This content is not available due to your privacy preferences.Update your settings here to see it.

Researchers say the drug may have the potential to reduce severe immune response known as the cytokine storm seen in Covid-19 patients that can cause lethal organ damage.

Though reducing deaths was not an intended focus area in the study, the scientists noted that among patients who took at least 80 per cent of medication doses, there was one death in the fluvoxamine group. In the placebo group, there were 12 deaths.

“Given fluvoxamine’s safety, tolerability, ease of use, low cost, and widespread availability, these findings may have an important influence on national and international guidelines on clinical management of Covid-19,” Gilmar Reis, co-principal investigator, based in Belo Horizonte, Brazil, said in a statement.

This content is not available due to your privacy preferences.Update your settings here to see it.

The researchers hope to assess next whether the closely-related drug fluoxetine, which is part of the WHO Essential Medicines List, can be used interchangeably for Covid-19, and if combining fluvoxamine with other drugs could provide better treatment outcomes.

“Fluvoxamine is, so far, the only treatment that if administered early, can prevent Covid-19 from becoming a life-threatening illness,” Edward Mills, co-principal investigator for the “Together Trial” from McMaster University in Canada, said.

“It could be one of our most powerful weapons against the virus and its effectiveness is one of the most important discoveries we have made since the pandemic began,” Dr Mills added.

The scientists however caution that the use of interventions like fluvoxamine to prevent Covid-19 disease progression and hospitalisation is “critically dependent” on reliably identifying patients at the highest risk of deterioration in the early stages of infection.

“The study strongly suggests that fluvoxamine constitutes an effective, safe, inexpensive, and relatively well-tolerated option for the management of ambulatory patients with Covid-19, which is particularly useful for (but not limited to) low-resource settings,” the researchers wrote.

Since the patient population recruited for the study were required to have at least one factor for more severe disease to start the fluvoxamine treatment, the impact on more severe outcomes remains uncertain.

In a linked commentary, Otavio Berwanger of the Academic Research Organisation of Hospital Israelita Albert Einstein in Sao Paulo, Brazil, said some questions related to the efficacy and safety of fluvoxamine for Covid-19 patients remained open even though the drug was commonly prescribed for mental illnesses like depression.

“It remains to be determined whether fluvoxamine has an additive effect to other therapies such as monoclonal antibodies and budesonide, and what is the optimal fluvoxamine therapeutic scheme,” he noted.

It is also unclear, according to Dr Berwanger, whether these findings extend to other outpatient populations with Covid-19 such as those without risk factors for disease progression, those who are fully vaccinated, and those infected with recent variants.

“Going forward, the inclusion of patients with vaccine breakthrough infection in trials of community-based interventions will be important, and trial protocols should be amended to enable inclusion of this important subgroup with appropriate pre-treatment stratification and sample size adjustment to enable meaningful conclusions to be reached,” Penny Ward, visiting professor in pharmaceutical medicine at King’s College London, said.

Internet Explorer Channel Network
Asia's Tech News Daily
News Related

OTHER NEWS

Ninja vs Nutribullet: which blender brand is right for you?

When it comes to getting more fruit and vegetables in our diet, smoothies are taking over. More than half of us enjoyed a refreshing and nutritious treat last year (and ... Read more »

Intel Alder Lake CPU problems with games now fixed – except for 3

Intel’s Alder Lake processors stumbled out of the gate when it came to gaming, having trouble with the DRM countermeasures implemented in some titles – but now all these issues ... Read more »

Does having an European HQ still matter in a ‘remote' world? Absolutely

Nearly every company has had to adjust to a distributed working model since the pandemic hit, with workers now dispersed to a wide range of locations and time zones. One ... Read more »

HP Omen 16 (2021) launched in India with 11th Gen Intel processor: Check price, specs

The HP Omen 16 features a 16.1-inch IPS display with a QHD resolution of 2560×1440 pixels. HP Omen 16 launched in India is the company’s new gaming laptop that features ... Read more »

New reporting dates given to 20 would-be detainees turned away from York County Jail

York County Superior Court Judge Richard Mulhern on Friday, Dec. 3, gave new reporting dates to more than 20 criminal defendants who were sentenced to self-report to the York County ... Read more »

Missed the Fitbit Charge 5 on Black Friday? It's back to its sale price right now

The Fitbit Charge 5 is down to just $129.95 at Amazon right now – the same as its Black Friday sale price, and a saving of $50. It’s the cheapest ... Read more »

Analysis: How to Help Students Reconnect to Teachers & Peers

Even before the COVID-19 pandemic, survey after survey showed teens in the United States were facing high, rising levels of stress and anxiety. The alarm now rings loudly for us ... Read more »

The Seagate FireCuda 530 is down to its lowest-ever price with this PS5 SSD deal

Black Friday and Cyber Monday may have been and gone, but the terrific PS5 SSD deals keep on coming. In the US the Seagate FireCuda 530 SSD 1TB with heatsink ... Read more »

In Horizon Forbidden West Aloy is much tougher, but so are the machines

Guerrilla’s latest official PlayStation Blog post details all things combat in Horizon Forbidden West. The upcoming PS5 adventure has had no shortage of blog post updates in the run up ... Read more »

Samsung Galaxy Tab S8 Ultra's notch may not be as bad once thought, new leak corroborates dual selfie camera rumors

Samsung Galaxy Tab S7+ | Photo credit: Samsung / YouTube screenshot The display notch may have been removed from many smartphones over the last two years, but it is certainly ... Read more »

Simon Cowell's new TV show Walk The Line hit by technical blunders

© Provided by Daily Mail MailOnline logo It’s set to hits screens on December 12.  But, Simon Cowell‘s new talent show Walk The Line was hit by technical blunders while ... Read more »

Stellantis targets €20 billion in revenue through connected vehicle software upgrades

Stellantis is planning to generate up to €20 billion (£16.9bn) in incremental annual revenue by 2030 through connected cars and over-the-air updates. The car giant, which owns Abarth, Alfa Romeo, ... Read more »

Journalists 'went to No.10 Xmas parties and want to bury story', claims Cummings

Dominic Cummings has said political journalists attended lockdown Christmas events at Downing Street. (PA) Political journalists attended alleged Christmas parties at Number 10 Downing Street during the coronavirus lockdown last ... Read more »

OnePlus Buds Z2 said to launch in India soon: Expected price and features

NEW DELHI: OnePlus is likely to soon expand its audio devices portfolio in India. According to reports, the company is set to launch OnePlus OnePlus Buds Z2 true wireless earbuds ... Read more »

Ministerstwo Zdrowia: 19 366 nowych zakażeń koronawirusem i 504 ofiary śmiertelne

Medycy podczas pandemii koronawirusa (zdjęcie ilustracyjne) Medycy podczas pandemii koronawirusa (zdjęcie ilustracyjne) Medycy podczas pandemii koronawirusa (zdjęcie ilustracyjne) We wtorek 7 grudnia Ministerstwo Zdrowia poinformowało o wykryciu 19 366 nowych ... Read more »

Best productivity tools of 2021

<div data-image="https://cdn.mos.cms.futurecdn.net/9Eh5mQqur3DifoRJkFZ3Fj-200-100.jpg" data-link="https://www.dpbolvw.net/click-6361382-14077115?sid=hawk-custom-tracking" data-link-text="View Deal" data-webp-image="https://cdn.mos.cms.futurecdn.net/9Eh5mQqur3DifoRJkFZ3Fj-200-100.jpg.webp" data-widget-introduction=" Google Workspace : Collaboration + productivity apps There are many different office software suites but Google Workspace formerly known as G Suite remains ... Read more »

Beijing leaves antitrust out of 2022 economic goals, focuses on technological development

China’s top policymaking body emphasised the country’s drive for technological self-sufficiency and innovation to address economic growth in 2022, shunning mentions of antitrust and the “disorderly expansion of capital” that ... Read more »

This upcoming Motorola phone will have the highest-resolution selfie camera ever

According to some teases, an upcoming Motorola phone could be one of the best smartphones for selfie-taking we’ve ever seen – or one of the worst, depending on how you ... Read more »

WhatsApp update: New chats can now be set to disappear by default, Meta adds more disappearing message durations

Photo credit: MIH83 / Pixabay Before Facebook became Meta, the social media empire faced widespread backlash over policy changes earlier this year that raised concerns on how it handles user ... Read more »

Narendra Modi, Amit Shah, Sonia Gandhi, Priyanka Chopra among those tested, jabbed for COVID in Bihar!

Narendra Modi, Amit Shah, Sonia Gandhi, Priyanka Chopra and Akshay Kumar – these are the names of residents of a non-descript rural area of an impoverished south Bihar district. If ... Read more »

The Arcane characters we want to see as League of Legends champions

It has now been over a month since the release of Arcane, the League of Legends (LoL) animated series on Netflix, and already fans of both the series and the ... Read more »

Shang-Chi is getting a sequel – and a comedy spinoff show

Shang-Chi and the Legend of the Ten Rings is getting a sequel and a Disney Plus comedy spinoff show, according to various reports. Following the Marvel movie’s successful stint at ... Read more »

Nowe dane o koronawirusie. Zmarło ponad 500 osób

© Karol Makurat/REPORTER Nowe dane o koronawirusie. Zmarło ponad 500 osób Koronawirus w Polsce. We wtorek 7 grudnia 2021 roku Ministerstwo Zdrowia potwierdziło 19 366 nowych przypadków zakażenia koronawirusem. Poinformowano ... Read more »

#LG Energy Solution submits registration for IPO

LG Energy Solution submits registration for IPO By Kim Byung-wook LG Energy Solution said Tuesday it has entered an official stage to go public in January, amid market expectation that ... Read more »

Samsung Galaxy Tab S8 leaked renders suggest the tablet will get a notch

The notch is probably one of the most controversial design elements in the tech world. While the Android side has gradually evolved by adopting designs like a pop-up camera, a ... Read more »

China Crystal New Material Holdings to raise 6.5 bln won via stock offering

SEOUL, Dec. 7 (Yonhap) — China Crystal New Material Holdings Co.on Tuesday announced that it will sell stocks to raise 6.5 billion won (US$5.5 million). The proceeds from the stock ... Read more »

Pixel Buds A-Series firmware update with higher bass range and improved device switching to roll out ‘in the coming days'

Photo credit: Eriel Suarez / Unsplash Firmware updates for wireless earbuds are usually uneventful, but that is not the case with the upcoming firmware version 282 for Pixel Buds A-Series. It is confirmed ... Read more »

What are Soundmojis: How to find them on Facebook

Facebook Messenger introduced a new feature called Soundmojis earlier this year. The Soundmojis let you send short sound clips in a Messenger chat. From clapping, crickets, drumroll and evil laughter, ... Read more »

NICD: Hospitals should be prepared for COVID-19 fourth wave infections

© Guillem Sartorio / AFP FILE: A patient infected with COVID-19 at the Tembisa Hospital in Gauteng on 2 March 2021. CAPE TOWN – The South African Medical Association (Sama) ... Read more »

‘The Matrix Awakens': How to download Unreal Engine 5 demo on PS5 and Xbox Series X/S

From the teaser for “The Matrix Awakens” | Photo credit: Unreal Engine / YouTube screenshot Epic Games confirmed the release of an upcoming demo of its Unreal Engine 5 called ... Read more »

HP Omen 16 gaming laptop launched in India: Price, specs and more

HP has launched the new HP Omen 16 gaming laptop in India. The new device features a 16.1-inch screen with 16:9 aspect ratio suited for both casual and seasoned gamers. ... Read more »

Nowy Jork. Pracownicy sektora prywatnego będą musieli zaszczepić się przeciwko COVID-19

Burmistrz Nowego Jorku Bill de Blasio zarządził w poniedziałek obowiązek szczepień przeciwko COVID-19 dla pracowników sektora prywatnego w mieście. Decyzja wchodzi w życie od 27 grudnia. Jest to pierwsze w ... Read more »

Hyundai Genuine to sell new shares worth 100 bln won to acquire stake in subsidiary

By Nam Kwang-sik SEOUL, Dec. 7 (Yonhap) — Hyundai Genuine Co. said Tuesday its board of directors has decided to sell new shares and raise 100 billion won (US$846 million) ... Read more »

Bengaluru doctor who recovered from Omicron tests COVID positive again

The city-based doctor, who had tested positive for Omicron variant of COVID-19 and reportedly recovered, has once again tested positive for the virus. The doctor was among the first two ... Read more »

Samsung is merging mobile and consumer electronics divisions: The big changes this means

Samsung Electronics Co Ltd said it will merge its mobile and consumer electronics divisions and named new co-CEOs in its biggest reshuffle since 2017, to simplify its structure and focus ... Read more »

Apple iPhone 13 vs Samsung Galaxy S21: Which smartphone is best?

(ES Composite) Every year the battle for the best phone reaches new heights, but this time around it feels particularly fierce. The pandemic forced us all to stay at home, ... Read more »

Covid news - live: Omicron to be dominant variant ‘within weeks' as India warns of ‘massive third wave'

Omicron is likely to become the dominant variant of coronavirus in the UK “in a matter of weeks,” a top scientist has warned. Dr Jeffrey Barrett, director of the covid-19 ... Read more »

PS5 UK stock - live: Argos, AO, Very and Amazon could restock consoles this week

Who could restock the elusive console today? (iStock/The Independent) UPDATE: The PS5 could restock at Argos, AO, Very and Amazon this week. Read on for more information. It has now ... Read more »

Dan Walker has the perfect response to Piers Morgan's Strictly dig

Dan Walker had the perfect response to Piers Morgan’s jibe over his exit from Strictly Come Dancing. The BBC Breakfast host and his professional dance partner Nadiya Bychkova were eliminated ... Read more »

Best SQL online courses in 2022

The best online SQL courses make it simple and easy to learn SQL for databases, covering everything from beginner to advanced users. The Structured Query Language or SQL as it ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic