Food stores that operate on the pavement have no customers at 9 p.m., a time which is usually considered the peak of business activities.
The majority of hotels on Ma May street have been forced to suspend operations.
A similar situation is occurring for many travel agencies in the area, with some trying to remain open, despite serving no customers.
Souvenir shops are forced to shut down with several owners unable to pay rent for several months.
While many local businesses have survived the first COVID-19 wave, they now face difficulties as the virus recurs, threatening their business again.
A look at Ma May street during the first social distancing period in April
The quietness of the area has left many businesses on one of the most bustling streets in Hanoi very concerned.