First case of LEOPARD syndrome reported in Vietnam

LEOPARD is a very rare disease that only a few dozen people have ever had.

An eight-year-old girl in the southern province of Tien Giang has been diagnosed with LEOPARD syndrome, which is the first case in Vietnam, according to Dr. Tran Nguyen Anh Tu, deputy head of the department of skin aesthetics at the Ho Chi Minh City Dermatology Hospital.

LEOPARD is a very rare disease that only a few hundreds of people have ever had, Tu said, adding that since it was first recorded in 1936, there have only been 200 confirmed cases worldwide so far.

First case, LEOPARD syndrome, Ho Chi Minh City Dermatology Hospital

 The body of the girl diagnosed with LEOPARD syndrome appears with multiple brown skin spots (lentigines). Photo: Ho Chi Minh City Dermatology Hospital

The girl’s family said dark-brown stains (lentigines) began appearing all over the face and body of the little girl since she was four years old.

She was born deaf and unable to speak, with physical and mental disabilities, abnormalities in the jawbone, spine, shoulder, chest, and teeth.

These are all typical signs of LEOPARD syndrome and no one in her family had the same disease.

Because of the disease, the patient is only 105cm tall and weighs 15kg. She has dark brown spots less than 5mm in diameter on the face, chest, arms and legs. The lighter brown spots of 2x3cm are on the back.

Genetic analysis at the Center for Molecular Biology of the Ho Chi Minh City University of Medicine and Pharmacy identified that the patient suffered from PTPN11 genetic mutations, which is believed to cause the very rare condition.

"This is consistent with LEOPARD syndrome due to the PTPN11 gene mutation, accounting for 90% of the cases," Dr. Tu said.

The patients diagnosed with LEOPARD syndrome need to be closely medically monitored and have their heart checked once a year for early diagnosis of abnormalities, Dr. Tu noted, adding that symptoms are treated appropriately.

In the world, the latest case of leopard syndrome was reported in 2017, a 12-year-old boy in Brazil. In 2015, a 22-year-old female patient was recorded in India.

The acronym LEOPARD describes the features of the syndrome:- (L)entigines - dark spots on the skin- (E)lectrocardiographic conduction defects - abnormalities of the electrical activity of the heart- (O)cular hypertelorism - widely spaced eyes- (P)ulmonary stenosis - obstruction of the normal outflow of blood from the right ventricle of the heart- (A)bnormalities of the genitalia- (R)etardation of growth resulting in short stature - (D)eafness.

News Related


Covid-19 shuts down schools in Da Nang, Quang Nam again

Following the long holidays April 30 and May 1 when people traveled a lot, the People’s Committee in Quang Nam allowed children in preschools, kindergartens, and schoolers in high schools, universities in the… Read more »

Numerous Vietnamese students begin stay home over latest Covid-19 outbreak

Ten cities and provinces across Vietnam have decided to close schools from May 4 in order to curb the infection of novel coronavirus-caused respiratory sickness. The closure, ranging from kindergarten to universities, was… Read more »

Vietnam sends experts to support Laos in COVID-19 fight

Minister of Health Nguyen Thanh Long speaking at the meeting with Vietnamese experts on May 3. (Photo: NDO – A delegation of 35 Vietnamese medical experts left for Laos on May 4… Read more »

14-day concentrated quarantine period to be extended

Illustrative image NDO – The Ministry of Health has issued an urgent message stating that people who have completed their 14-day quarantine period and tested negative for COVID-19 virus twice will not be… Read more »

From May 4, people completing 14-day quarantine period asked not to leave

Head of the Health Ministry’s Department of Preventive Medicine Nguyen Quang Tan this morning sent an urgent paper to directors of centers for disease control and departments of preventive medicine in cities and… Read more »

Hanoi detects new COVID-19 infection at Times City

The entrance of building Park 10 in Times City, Hanoi where the new COVID-19 patient, an Indian expert, and his family are living. (Photo: VNA) Hanoi (VNA) – An Indian expert, who works… Read more »

Over 30 Vietnamese experts ready for COVID-19 support mission in Laos

Minister of Health Nguyen Thanh Long speaks at the meeting (Photo: VNA) Hanoi (VNA) – A group of 35 Vietnamese doctors and caregivers is expected to leave Vietnam on May 4 for Laos… Read more »

Universities turn to online learning as pandemic continues

Specifically, Hanoi University of Science and Technology asked lecturers and students to use Microsoft Teams for online teaching and learning from May 4 to 9 while experimental sessions and practice are paused until… Read more »

Vietnam documents two new domestically-transmitted COVID-19 infections

A medical worker collects samples for COVID-19 testing (Photo: VNA) Hanoi (VNA) – The Ministry of Health confirmed four more COVID-19 cases, including two local infections, in the past 12 hours to 6:00… Read more »

Vietnam documents two news domestically-transmitted COVID-19 infections

A medical worker collects samples for COVID-19 testing (Photo: VNA) Hanoi (VNA) – The Ministry of Health confirmed four more COVID-19 cases, including two local infections, in the past 12 hours to 6:00… Read more »

19 new COVID-19 cases reported

A checkpoint established in Ly Nhan district, Ha Nam province (Photo: VNA) Hanoi (VNA) – Vietnam has 19 new cases of COVID-19 to report for the past 12 hours to 6pm of May… Read more »

HCMC authorities inspect Covid-19 prevention, control work

HCMC People’s Committee Vice Chairman Duong Anh Duc leads a delegation to inspect the epidemic prevention and control at Binh Dien whosale market. (Photo: SGGP) Several people wear masks that are not in… Read more »

No COVID-19 cases recorded on May 3 morning

A delegation from the Ministry of Health is inspecting COVID-19 prevention and control measures in Ha Nam province (Photo: VNA) Hanoi (VNA) – Vietnam has no new cases of COVID-19 to report in… Read more »

Vietnam reports 20 more COVID-19 cases

Hanoi puts an apartment building under lockdown after a resident there was confirmed positive for the coronavirus. (Photo: VNA) Hanoi (VNA) – Vietnam has 20 new cases of COVID-19 to report for the… Read more »

Personal, collective resonsibility on COVID-19 spread must be made clear: PM

Prime Minister Pham Minh Chinh (standing) at the working session with the National Steering Committee on COVID-19 Prevention and Control on May 2 (Photo: VNA) Hanoi (VNA) – Prime Minister Pham Minh Chinh has… Read more »

People returning to Hanoi after holidays must make medical declaration

In an urgent dispatch signed on May 2, Chairman of Hanoi People’s Committee Chu Ngoc Anh urged heads of districts and towns in Hanoi to tighten Covid-19 pandemic control and prevention as the… Read more »

Morning May 2: No new Covid-19 infections detected in Vietnam

As of 6am, May 2, 2021, the total number of confirmed Covid-19 cases remained at 1,587, of whom 927 were new cases detected between January 27 and May 2, 2021.   Localities around the… Read more »

Ministry implements project to improve students’ awareness of startup

Moreover, the Ministry’s project will help students to proactively access to the supporting system inside and outside their schools. The project guides educational and training institutions to organize models to support student business… Read more »

Vietnam sets up makeshift hospital as local coronavirus infections surge

A makeshift hospital in anticipation of rising local coronavirus infections has been set up in the northern province of Ha Nam, home to the first locally-infected cases in months. The makeshift hospital with… Read more »

HCMC strives for 20 percent of students having int'l computer certificates

The project contents were released at a conference to implement the project “Improving the capacity, knowledge and skills of IT application for high school students in HCMC according to international standard orientation period… Read more »

HCMC strives for 20 percent of students having int'l computer certificatificates

The project contents were released at a conference to implement the project “Improving the capacity, knowledge and skills of IT application for high school students in HCMC according to international standard orientation period… Read more »

Education authority orders teachers, students to strictly follow 5K principles

5K principles (in Vietnamese) means “Khau trang” (face mask) – “Khu khuan” (disinfection) – “Khoang cach” (distance) – “Khong tu tap” (no gatherings) – “Khai bao y te” (health declaration). In its papers,… Read more »

Hack4Growth 2021 kicks off in Australia

Hack4Growth 2021, initiated by Startup Vietnam Frontier – Australia (SVF-AU) and the Vietnam Australia Innovation Network Inc (NIC-AU), have just kicked off in Australia. The event, with the aim of promoting the ecosystem… Read more »

Da Nang ranks 1st for 12th year in information technology development and application index

A corner of Da Nang City (Photo: VOV) On April 27, within the framework of Digital Transformation Week – Hue 2021, the Vietnam Association For Information Processing and the Department of Information Technology… Read more »

Vietnamese grandmaster qualified for international chess tournament

Vietnamese grandmaster Le Quang Liem has qualified for the quarterfinals of the New In Chess Classic after he had finished seventh with 8.5 points in the qualifying round. The international tournament is held… Read more »

Pharmaceutical giants shell out billions to shareholders as world confronts vaccine apartheid

This would be enough to pay to vaccinate at least 1.3bn people, the equivalent of the population of Africa.  The shareholder meetings begin on 22nd April with Pfizer and Johnson and Johnson followed… Read more »

Smart Education Operations Center in Quang Nam inaugurated

Currently, most schools in Quang Nam province have been using school management software; banking management software exam questions; testing marking software, equipment management software to benefit teachers. The above-mentioned factors are very favorable… Read more »

Vietnam-made Covid-19 vaccine proves immunogenic

Vietnam has completed the second phase of human trial of Nanocovax’s Covid-19 vaccine, which has proven immunogenic on all volunteers, according to researchers at Vietnam Military Medical University. Initial results showed all 556… Read more »

Hanoi, Saigon students squeeze time for extra classes as high school entrance exam nears

With the high school entrance exam over two months away, final-year students at middle schools in Hanoi and Ho Chi Minh City are cramming for the test in back-to-back extra classes, hoping for a… Read more »

Vietnam publisher apologizes Australian author, pulls journalism book over plagiarism

A publisher in Vietnam has apologized an Australian author and recalled a book on journalism and communication after he found two university lecturers who are the writers of an article in the book… Read more »

Three Hanoi universities break into THE Impact Rankings

Three universities in Hanoi have broken into the Impact Ranking 2021 released by the Times Higher Education (THE) on April 21. Of them, Vietnam National University, Hanoi (VNU-Hanoi) is ranked in the group… Read more »

RCS recognizes Viet-Duc Hospital as global training center

Vietnam-German (Viet-Duc) Friendship Hospital has been recognized as a training center, which  meets global standards by the UK Royal College of Surgeons (RCS). The certification will expire in February 2024. Vietnam-German Friendship Hospital… Read more »

Influential Vietnamese teacher of English carves success out of passion

Despite his training in biotechnology, Nguyen Thai Duong, hailing from Ho Chi Minh City, made a bold choice to become an English teacher and has been riding a wave of success and popularity… Read more »

Ministry encourages swimming classes to reduce risk of drowning

The plan will be carried out from now to the end of November 2021. The plan aims to raise teachers, students and parents’ awareness of drowning accident to actively prevent accidents, injuries and… Read more »

Australia and UNICEF support Vietnam in Covid-19 vaccine delivery

The Australian Embassy and the United Nations Children’s Fund (UNICEF) have announced an assistance worth US$10.5 million to support Covid-19 vaccine delivery in Vietnam, ensuring the country’s expanded immunization program. Australian Ambassador to… Read more »

Thousands of inventions successfully applied in life and production

Prof. Dr. Dang Vu Minh, former VIFOTEC Chairman, congratulates Dr. Phan Xuan Dung, VIFOTEC Chairman. (Photo: HNMO) So said Dr. Le Xuan Thao, Standing Vice Chairman of the VIFOTEC Sponsor Council, on April… Read more »

Ministry petitions for unchanged tuition to share financial burden with students

Many universities and colleges’ announcements of rising tuition fee have made students worry; therefore, the Ministry has called for unchanged fees. Ministry petitions for unchanging tuition fee to share financial burden with students… Read more »

Students suffer from allegedly contaminated food at two schools in Hanoi

Six students at two schools under the same system in Bac Tu Liem District, Hanoi were hospitalized on Friday and 20 others suffered stomach pain, persistent defecation and vomited after all of them had had school meals the… Read more »

International cooperation opens up more opportunities for students

The Ho Chi Minh City Vocational Education Association held a conference “Connecting international cooperation in the vocational education system” with the attendance of leaders of the General Department of Vocational Education, Ministry of… Read more »

Australia-UNICEF partnership on vaccine delivery assistance in Vietnam

Working closely with the Vietnamese Ministry of Health, the Australia-UNICEF partnership will provide a unique and holistic support package that will help facilitate the successful introduction and deployment of the COVID-19 vaccines through… Read more »

HCMC increases supervision over students’ online learning for cyber safety

According to the Department’s document, heads of education divisions in Thu Duc City and 21 districts, principals of high schools and vocational training institutions must support students to engage with digital technology in… Read more »

Pedagogy schools find it hard to lure good students despite gov’t efforts

According to the Government’s Decree 116, students in pedagogy schools will receive an amount of VND3.63 million per month as living expense from November 2020. Thus, in addition to total tuition fee exemption,… Read more »

This one-legged Vietnamese student is painting her future

Determined not to let her disability stop her from reaching her goals, Nguyen Thi Cam Nhung, from Ben Tre Province in Vietnam’s Mekong Delta, is pushing herself toward a bright future regardless of the… Read more »

Vietnam officially approves online schooling

Vietnam’s Ministry of Education and Training has just authorized online classes to support or replace face-to-face teaching and learning. According to a new circular issued by the ministry, the school principals can decide… Read more »

Vietnamese grandmaster to coach American university chess team

Le Quang Liem, the number one chess player in Vietnam, has been appointed the new coach of the Webster University in the US from June. Liem will take over the position from Susan… Read more »

Micro-satellite NanoDragon complete testing and ready for launch into orbit

Micro-satellite NanoDragon  (Source: the Vietnam National Space Center) The device was sent to the Kyushu Institute of Technology in Japan in order to undergo quality control in an environment which aims to simulate the… Read more »

Candidates begin to apply for national high school graduation examination

The Ministry of Education and Training April 12 held a training conference for the 2021 high school graduation examination at Vietnam Maritime University in the Northern City of Hai Phong. Deputy Minister of… Read more »

MoET launches contest about studying and following Uncle Ho

The contest is expected to attract some 1.5 million contestants. (Photo: According to Mr. Bui Van Linh, Head of Department of Political Education and Student Affairs under MoET, the contest is a… Read more »

Hanoi man runs library to offer free English books to children to promote creativity

A local man is operating a free-of-charge library in Hanoi, satisfying the reading needs of everybody and creating a convenient space for its visitors to communicate in English. The library, situated on Kim… Read more »

First six volunteers receive second shots of second local COVID-19 vaccine trials

One of six volunteers receive second shots of second local COVID-19 vaccine trials(Source: They are the first out of the total 120 volunteers in the trials to receive the second shot, which is administered… Read more »