Bharat Biotech vaccine for drug-resistant typhoid found safe, effective for children under 12

© Provided by The Print

New Delhi: A Bharat Biotech vaccine that prevents typhoid fever, caused by a drug-resistant bacteria and prevalent in Africa, has been found to be safe and effective for children under the age of 12 in Phase 3 clinical trials.  

The typhoid fever, caused by H58 Salmonella Typhi, a type of bacteria that has become resistant to multiple drugs, is an increasing public health threat in sub-Saharan Africa.

A team of scientists, including researchers from University of Oxford, conducted a Phase 3, double-blind trial in Blantyre, Malawi, to assess the efficacy of Vi polysaccharide typhoid conjugate vaccine (Vi-TCV). 

Developed by Bharat Biotech, the Vi-TCV or Typbar TCV — the world’s first clinically proven conjugate Typhoid vaccine — contains a carbohydrate from the Salmonella typhi Ty2 bacteria, along with the Tetanus vaccine.

While the Salmonella typhi carbohydrate alone elicits B cell responses, the inclusion of the tetanus vaccine elicits higher-affinity antibodies and long-term immune memory.

Such a vaccine is known as conjugate vaccines — where a weak antigen is combined with a strong antigen — so that the immune system has a stronger response. An antigen is a part of the pathogen that the body can identify. 

The Typbar TCV is the world’s first clinically proven conjugate Typhoid vaccine. 

India’s top virologist Dr Gagandeep Kang, who is also a professor at the Christian Medical College in Vellore, also tweeted on the development.

An Indian made typhoid vaccine ready to solve problems in Africa-great, long awaited data here. Gavi Alliance is supporting vaccine introductions in Asia and Africa.

Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children | NEJM https://t.co/hNKoDmHUBu

— G Kang (@GKangInd) September 18, 2021

The Phase 3 trials

In the latest clinical trial, the results of which have been published in the journal NEJM, researchers randomly assigned 28,130 children who were between 9 months and 12 years of age to either receive a single dose of Vi-TCV or meningococcal capsular group A conjugate (MenA) vaccine. 

Blood culture tests confirmed typhoid fever occurred in 12 children among the 14,069 children in the Vi-TCV group and in 62 children in the MenA group of 14,061 children. 

Among Malawian children, administration of Vi-TCV resulted in a lower incidence of blood culture, confirmed typhoid fever, than the MenA vaccine. The vaccine was found to provide a protective efficacy of 80.7 per cent.  

The efficacy of Vi-TCV was similar in children who were younger than five years of age and children who were five years of age or older at the time of vaccination, and this efficacy remained consistent throughout the observation period. 

In total, 130 serious adverse events occurred in the first 6 months after vaccination — 52 in the Vi-TCV group and 78 in the MenA group — including 6 deaths (all in the MenA group). No serious adverse events were considered by the investigators to be related to vaccination.

In their papers, researchers noted that efficacy of Vi-TCV after 18 to 24 months was consistent with a previously reported efficacy of 81.6 per cent after 12 months of follow-up among Nepalese children of 9 months to 16 years of age.

The team said that despite a 2008 WHO recommendation for programmatic use of existing vaccines in countries in which typhoid is endemic, no African country integrated these vaccines into routine schedules, largely because of the unsuitability of their use in the youngest children and the need for repeated doses. 

Malawi, where the trial was conducted, has a high prevalence of typhoid among school-age and preschool children.

Based on their findings, the team now recommends a routine introduction of Vi-TCV among infants, coupled with catch-up campaigns targeting children up to the age of 15 years to control drug-resistant typhoid. 

(Edited by Arun Prashanth)

Also read: Biocon partners SII to make vaccine, drug manufacturing accessible to developing nations

Internet Explorer Channel Network
News Related

OTHER NEWS

Protesters burn tires, block roads in Sudan a day after coup

Pro-democracy protesters flash the victory sign as they take to the streets to condemn a takeover by military officials, in Khartoum. Pro-democracy protesters blocked some roads in Sudan’s capital with ... Read more »

South Africa vs West Indies, ICC T20 World Cup 2021, Live Cricket Score: Lewis' 50* gives WI a good platform as SA struggle for breakthrough

16:10:52 IST FIFTY up for Lewis! 50 (32) 16:10:35 IST SIX! Shamsi sends it down leg and Lewis gets down on one knee and connects beautifully with the slog-sweep to bring up ... Read more »

This game should bring people together, not divide them- Rizwan speaks in support of Shami in view of online abuse

© Provided by Hindustan Times This game should bring people together, not divide them- Mohammad Rizwan speaks in support of Mohammed Shami in view of online abuse after India vs ... Read more »

Ahead of UP Elections, BSP Leaders Switching Over to Akhilesh Yadav's SP

© Provided by News18 Ahead of UP Elections, BSP Leaders Switching Over to Akhilesh Yadav’s SP The Buwa-Bhatija duo was expected to pull off a miracle in Uttar Pradesh during ... Read more »

CBI Arrests Serving Navy Officer, 2 Retired Personnel for Leaking Info Related to Submarine: Report

© Provided by News18 CBI Arrests Serving Navy Officer, 2 Retired Personnel for Leaking Info Related to Submarine: Report The Central Bureau of Investigation (CBI) has arrested a serving Indian ... Read more »

Suriya takes the stand on his upcoming courtroom drama 'Jai Bhim'

© IANS Jai Bhi. Chennai, Oct 26 (IANS) Suriya Siva Kumar stars as an advocate in upcoming courtroom drama ‘Jai Bhim’ which will have an OTT release on Prime Video ... Read more »

South Africa vs West Indies Live Score, T20 World Cup 2021: Simmons, Lewis take Windies off to strong start

© Provided by Firstpost South Africa vs West Indies Live Score, T20 World Cup 2021: Simmons, Lewis take Windies off to strong start 15:57 (IST) After 6 overs,West Indies 43/0 ... Read more »

Raveena Tandon turns 47. Shilpa Shetty to Juhi Chawla, Bollywood says happy birthday

Shilpa Shetty and Juhi Chawla wished Raveena Tandon a happy birthday. Raveena Tandon is celebrating her 47th birthday today, October 26. Her friends and colleagues from the industry took to ... Read more »

T20 World Cup: Including Hardik Pandya in squad against Pakistan was India's biggest setback, says Inzamam-ul-Haq

© Provided by Zee News DUBAI: Former Pakistan captain Inzamam-ul-Haq has claimed that the selection of all-rounder Hardik Pandya in the playing XI against Pakistan was one of India’s biggest ... Read more »

Maintain unity and discipline, Sonia tells partymen

© Provided by The Statesman Maintain unity and discipline, Sonia tells partymen As her faction-ridden party gears up for the crucial assembly elections in five states, Congress President Sonia Gandhi ... Read more »

Bachelorette's Katie Thurston and Blake Moynes announce SPLIT 3 months after getting engaged on the show

© Provided by Pinkvilla Bachelorette stars Katie Thurston and Blake Moynes took to Instagram to announce their split on Monday, October 25. Nearly after 3 months since the duo got ... Read more »

T20 World Cup 2021-Quinton de Kock Pulls Out of West Indies Clash After Cricket South Africa's New BLM Guidelines

© Provided by News18 T20 World Cup 2021-Quinton de Kock Pulls Out of West Indies Clash After Cricket South Africa’s New BLM Guidelines South Africa wicket keeper batter and one ... Read more »

Pakistan vs New Zealand Live Streaming ICC T20 World Cup 2021: When and where to watch PAK vs NZ in India

© Provided by Zee News The manner in which the Babar Azam-led Pakistan crushed India in their opening game of the ICC T20 World Cup ‘Super 12’ would have given ... Read more »

3 Cathie Wood Stocks to Watch This Earnings Season

After delivering enormous gains in 2020, the collection of exchange-traded funds or ETFs Cathie Wood manages for ARK Invest have underperformed this year. Is the internet’s favorite stock market prognosticator ... Read more »

Sanders faces difficult choice on slimmed-down budget bill

© Greg Nash Sen. Bernie Sanders (I-Vt.) arrives to the Capitol for nomination votes on Monday, October 25, 2021. Sen. Bernie Sanders (I-Vt.) is facing a gut-wrenching decision about whether ... Read more »

Lilly raises 2021 outlook on higher COVID-19 drugs sales

FILE PHOTO: An Eli Lilly and Company pharmaceutical manufacturing plant is pictured in Branchburg, New Jersey (Reuters) -Eli Lilly and Co raised its full-year profit and revenue forecasts on Tuesday, ... Read more »

Top corporate updates: Nestle's Rs 110 dividend, Infosys' Rs 15 dividend, Godawari Power & Ispat bonus ex-date today

© Provided by Zee Business There are a few important corporate developments lined up for shareholders on Tuesday.  Nestle India, Infosys will offer dividends of Rs 110 per share and Rs 15 stock a piece respectively, while Godawari Power and Ispat ... Read more »

Amazon Great Indian Festival Finale Days: Best Diwali 2021 deals

© Provided by Zee News New Delhi: The Amazon Great Indian Festival Finale Days are here, and buyers can take advantage of some of the best prices and offers available ... Read more »

College, university students can download Bill Gates' book ‘How to Avoid a Climate Disaster' for free

© Jagyaseni Biswas College, university students can download Bill Gates’ book ‘How to Avoid a Climate Disaster’ for free Microsoft co-founder Bill Gates on October 25 announced that his book ... Read more »

Chalo acquires Shuttl, accelerates plan for International expansion

© Provided by CNBCTV18 In a strategic move, public transport technology company Chalo has acquired Shuttl, the app-based office commute bus aggregator for an undisclosed amount. Prior to COVID-19, Shuttl ... Read more »

What is a climatarian diet?

© Provided by The Independent A ‘Climatarian’ diet focuses on plant-based and locally sourced foods (Alamy/PA) – If you want to reduce your personal impact on the environment, you might ... Read more »

England will attack, but 'also give you chances' - Ottis Gibson wants Bangladesh bowlers not to panic

© ICC via Getty “We know they will come out hard, but they also give you chances” – Ottis Gibson to the Bangladesh bowlers © ICC via Getty Ottis Gibson ... Read more »

Bacardi creates limited-edition bottles that glow-in-the-dark for Halloween

Are you throwing a little Halloween party this weekend? Or perhaps just looking for an extra special tipple to add on your bar cart or alcoholic shelf? Because Bacardi might ... Read more »

Sanjiv Goenka makes a billion dollar comeback to the world's biggest T20 stage

© BCCL Sanjiv Goenka makes a billion dollar comeback to the world’s biggest T20 stage The Sanjiv Goenka-led RPSG group has bagged the Lucknow franchise of the IPL. Goenka is ... Read more »

CBI arrests Navy officers in information leak case

© Provided by Zee News New Delhi: In a significant development, the Central Bureau of Investigation (CBI) has arrested a serving Indian Navy officer along with two retired ones in ... Read more »

South Africa vs West Indies, ICC T20 World Cup 2021, Live Cricket Score: Lewis on a roll, Klaasen drops Simmons on 6

15:56:51 IST DROPPED! Simmons looks to guide the ball to third man but gets a healthy edge which Klaasen doesn’t latch on to. That could be expensive!  15:55:50 IST FOUR! Lewis is ... Read more »

Winter Session of Parliament likely to be held from 29 November to 23 December

© Provided by Firstpost Winter Session of Parliament likely to be held from 29 November to 23 December The Winter Session of Parliament is likely to begin from 29 November ... Read more »

Cricket South Africa directs players to take the knee during ICC T20 World Cup 2021

The Cricket South Africa (CSA) on Monday evening unanimously agreed to issue a directive requiring all Proteas players to adopt a consistent and united stance against racism by “taking the ... Read more »

Naveen-ul-Haq returns to Leicestershire for 2022 season

© Tony Marshall / © Getty Images Naveen-ul-Haq picked up 26 wickets in the 2021 T20 Blast at 17.57 Tony Marshall / © Getty Images Naveen-ul-Haq, the Afghanistan seamer who ... Read more »

Watch: Burn fat and gain strength with 5 HIIT exercises by Yasmin Karachiwala

With busy lifestyles and fast-paced routines, it gets tough to take time out for a quick workout. But to lead a healthy lifestyle, it is necessary to keep the mind ... Read more »

Delhi hospitals see surge in dengue cases, patients from UP pouring in

© Provided by Zee News New Delhi: Delhi hospitals are witnessing a surge in Dengue cases as the number of patients from the national capital and nearby areas, especially Uttar ... Read more »

Doctor Suggests 6 Ayurvedic Tips for Better Eye Care Protection

© KS Swati | India.com Lifestyle Staff Doctor Suggests 6 Ayurvedic Tips for Better Eye Care Protection. Picture Credits: Unsplash With online classes and work from home, we are spending ... Read more »

Bigg Boss 15: Tejasswi Prakash's Health Deteriorates Amid Captaincy Task, Karan Kundrra Lifts Her to Doctor

© Kritika Vaid | India.com Entertainment Desk Bigg Boss 15: Tejasswi Prakash’s Health Deteriorates Amid Captaincy Task, Karan Kundrra Lifts Her to Doctor Bigg Boss 15: The latest episode of ... Read more »

Stocking Up Your Kitchen? Here's The Ultimate List of Kitchen Essentials

© Anjali Thakur | India.com Lifestyle Staff Stocking Up Your Kitchen? Here’s The Ultimate List of Kitchen Essentials (Picture credit: Pixabay) A well-equipped and organized kitchen has the power to ... Read more »

Ensure safety of witnesses: Supreme Court tells UP government in Lakhimpur violence case

© Provided by DNA Hearing the Public Interest Litigation (PIL) filed in the Lakhimpur Kheri Violence Case, the Supreme Court on Tuesday directed the Uttar Pradesh government to ensure the ... Read more »

'They Are Hyenas, Once Sat at Amarinder's Feet': Aroosa Alam Slams Cheap Politics, to Take Legal Aid

© Provided by News18 ‘They Are Hyenas, Once Sat at Amarinder’s Feet’: Aroosa Alam Slams Cheap Politics, to Take Legal Aid Aroosa Alam, Captain Amarinder Singh’s long-time friend and Pakistani ... Read more »

The Crown to dedicate episode to Princess Diana on Panorama

© Bang Showbiz Princess Diana ‘The Crown’ will dedicate an entire episode to Princess Diana’s infamous interview with Martin Bashir. The upcoming fifth season of Netflix’s regal drama will feature ... Read more »

Zee Entertainment gets a breather, Bombay HC grants injunction against Invesco's call for EGM

© Maryam Farooqui Zee Entertainment gets a breather, Bombay HC grants injunction against Invesco’s call for EGM The Bombay High Court on October 26 granted an injunction against Invesco calling ... Read more »

EXCLUSIVE: Emraan Hashmi tested Covid-19 positive in Vienna – FINALLY hints at being a part of Tiger 3

© Provided by Pinkvilla Pinkvilla has given multiple updates on how Emraan Hashmi has joined Salman Khan and Katrina Kaif in the espionage thriller, Tiger 3. However, the actor has ... Read more »

Sunny Deol gets nostalgic as Indian turns 20: It is a film that will always remain a part of me

© Provided by Pinkvilla Bollywood actor Sunny Deol has recalled shooting for the 2001 movie ‘Indian’ in which he played the role of ‘DCP Rajshekhar Azad’. He said: “‘Indian’ is ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic