As Delta Sub-Variant AY.4.2 Spreads, How Worried Should We Be?

Asia's Tech News Daily

Data is slowly but increasingly suggesting that the COVID AY.4.2 variant has a growth advantage over other Delta types, according to a genomics expert.

© Justin Tallis/AFP / Getty A lab worker handles a sample for COVID testing in west London on January 21, 2021. AY.4.2 is mostly spreading in the U.K., sequencing data shows.

AY.4.2 is an evolution of the Delta AY.4 variant, the latter of which has been widely detected around the world, particularly in the United Kingdom.

AY.4.2 is characterized by two mutations in particular, in its spike genome: Y145H, and A222V. Scientists are still trying to figure out what these mutations might mean for the variant’s success.

The Delta offshoot has come under the spotlight over the past several days after experts noted a sharp rise in its prevalence in the U.K. from July onwards.

According to Outbreak.Info, which collects data on the spread of COVID variants from a virus database called GISAID, AY.4.2 accounts for between 7 and 8 percent of recent sequenced COVID samples in the U.K.

Details are still scarce, but it’s thought that, based on current data, AY.4.2 has a growth advantage of around 10 percent over other Delta variants.

It has been suggested that this could be down to luck or some sort of fluke, but this is looking increasingly unlikely, Jeffrey Barrett, director of the COVID-19 Genomics Initiative at the Wellcome Sanger Institute, told Newsweek.

“We are one of the groups that has observed a ~10% growth advantage compared to other Delta,” he said. “I’d say we can’t say for sure yet that that is a true biological advantage, as opposed to a bit of epidemiological ‘luck’ for this lineage, but the data are now accumulating week-by-week in favour of a small growth advantage.”

Things are still hazy as far as the variant’s mutations are concerned, however.

“A222V has been seen in a lineage from summer 2020 which spread around Europe pre-Alpha, but there was never strong experimental evidence of what that mutation might do, nor was there consensus it really gave a growth advantage in the wild,” Barrett added.

Things are perhaps even less clear regarding Y145H, which hasn’t really been seen before. There’s no lab data yet on its possible function.

In any case, AY.4.2 is still very rare in the U.S., though the Centers for Disease Control and Prevention (CDC) this week acknowledged that cases had been identified in the country.

In a White House COVID briefing on Wednesday, CDC director Rochelle Walensky said the Delta subvariant has “on occasion” been seen in the U.S. “but not with recent increased frequency or clustering to date,” according to the San Francisco Chronicle.

Walensky added there is no evidence that the variant impacts the effectiveness of current COVID vaccines.

And while AY.4.2 may be on the increase in the U.K., this doesn’t mean it’s going to take over in the same way the original Delta did, according to Oxford Vaccine Group chief Andrew Pollard.

Pollard told BBC Radio this week, as per the New York Post: “Indeed, even if it does, Delta is incredibly good at transmitting in a vaccinated population and a new one may be a bit better but it’s unlikely to change the picture dramatically from where we are today.”

Related Articles

  • Europe, Americas Lead Globe in New COVID Cases, 1B Vaccines Administered Worldwide: WHO
  • UK Government Urges Citizens Get COVID Booster Shot as Cases Surge to Over 49K
  • Russia Gets Work Stoppage Order As Some Hospitals Suspend Care for Non-COVID Patients

Start your unlimited Newsweek trial

Internet Explorer Channel Network
Asia's Tech News Daily
News Related

OTHER NEWS

AFC has record 12 teams at .500 or better through Week 12

The NFL has never quite seen a conference like this year’s AFC. Heading into December, only four teams in the conference have losing records, with the 12 teams at .500 ... Read more »

Charges filed against R.I. man accused of using table leg as club against police on Jan. 6

Charges have been filed against a Rhode Island man accused of attacking police with what appeared to be a broken wooden table leg during the Jan. 6 riot at the ... Read more »

Despite variants, Singapore's COVID-19 strategy on track

1 / 5Virus Outbreak SingaporePeople wearing protective face masks walk along the Orchard Road shopping area in Singapore on Nov. 28, 2021. When Singapore embarked upon its strategy of “living ... Read more »

India's Nykaa looks to triple store count in retail expansion-CEO

By Abhirup Roy MUMBAI (Reuters) – Indian cosmetics-to-fashion retailer Nykaa plans to more than triple its brick-and-mortar stores to 300, founder and Chief Executive Falguni Nayar said, significantly building its ... Read more »

China says 85% of citizens will use Mandarin by 2025

The Associated PressTibetan Buddhist nuns read from their textbooks as they attend a Chinese language learning class at the Tibetan Buddhist College near Lhasa in western China’s Tibet Autonomous Region, ... Read more »

Father of ‘Rust' armorer Hannah Gutierrez Reed provides new theory on how live ammo got on set

The father of “Rust” armorer Hannah Gutierrez Reed, an industry veteran himself, gave police a new theory for how live ammunition arrived on the set of the western film. Thell ... Read more »

Can HIV be prevented by taking pills? Prof Linda-Gail Bekker explains

© Provided by CapeTalk Copyright: markusgann / 123rf World AIDS Day is observed on the 1 December every year since 1988 and is an international day dedicated to raising awareness ... Read more »

Child pornography and sexual abuse cases bound over for trial court arraignment, one dismissed

Dec. 1—A child sexual abuse case scheduled for a preliminary hearing took a different turn Monday morning. Dustin Leroy Drake of Tulsa had the single charge of child sexual abuse ... Read more »

German state reports four fully vaccinated people infected with Omicron

People visit a Christmas market as the spread of the coronavirus disease (COVID-19) continues in Berlin BERLIN (Reuters) – Four people in southern Germany have tested positive for the Omicron ... Read more »

Sanofi to buy Origimm Biotechnology for acne vaccine candidate

FILE PHOTO: Sanofi logo is seen in Paris PARIS (Reuters) -French healthcare company Sanofi said on Wednesday it would buy Austrian group Origimm Biotechnology, a move that will add a ... Read more »

Japan emperor's daughter Aiko turns 20, throne not in sight

The Associated PressIn this photo provided by the Imperial Household Agency of Japan, Princess Aiko, daughter of Emperor Naruhito and Empress Masako, strolls in the garden of the Imperial Residence ... Read more »

Ducks blow late 3-goal lead, beat Kings 5-4 in shootout

LOS ANGELES (AP) — Kevin Shattenkirk and Trevor Zegras scored in the shootout, and the Anaheim Ducks blew a three-goal lead in the third period before rallying for a 5-4 ... Read more »

Moore carries San Jose State over South Dakota 61-52

SAN JOSE, Calif. (AP) — Omari Moore had 18 points and six rebounds as San Jose State beat South Dakota 61-52 on Tuesday night. Tibet Gorener had 14 points for ... Read more »

Nigeria confirms first cases of Omicron among travellers from South Africa

ABUJA (Reuters) –Nigeria confirmed its first cases of the Omicron COVID-19 variant among two travellers who arrived from South Africa last week, the Nigeria Centre for Disease Control (NCDC) said ... Read more »

Mourners pack church to grieve shooting victims

Mourners pack a Michigan church to grieve those killed and injured in a school shooting (Dec. 1) Read more »

It looks like Omicron variant causes milder illness – is this how Covid-19 becomes endemic?

© Provided by Independent Online (IOL) By Hamish McCallum These are very early days in terms of our understanding the Omicron variant. What is known is that it has a ... Read more »

'COVID-19 has brought significant challenges in fight against HIV/Aids'

© Provided by 702 As the world commemorates World Aids Day, South Africa has made gains in the treating of HIV. However, there is still much work that needs to ... Read more »

Video: 'We don't have a motive at this point' say police after Michigan school shooting

Student is apprehended by law enforcement officers after fatal shooting spree at a school which also left some critically injured. Read more »

Reliever Daniel Hudson returns to Dodgers on 1-year deal

LOS ANGELES (AP) — Right-handed reliever Daniel Hudson has returned to the Los Angeles Dodgers on a one-year contract. The Dodgers announced the deal Tuesday night for Hudson, who pitched ... Read more »

Sheriff: gun bought 4 days before school shooting

Oakland County, Michigan Sheriff Michael Bouchard says the gun used in a school shooting on Tuesday was purchased by the suspect’s father on November 26th. Three people were killed and ... Read more »

I bought my home for $30,000, but now it's worth almost $3 million. How can I avoid a massive tax bill?

I bought my home for $30,000, but now it’s worth almost $3 million. How can I avoid a massive tax bill? Capital gains aren’t the only factor to consider in ... Read more »

Trail Blazers snap 3-game skid with 110-92 win over Detroit

PORTLAND, Ore. (AP) — CJ McCollum scored 28 points and the Portland Trail Blazers handed the Detroit Pistons their seventh straight loss with a 110-92 victory on Tuesday night. Ben ... Read more »

Binnington rebounds, Blues rally to beat Lightning 4-3 in SO

ST. LOUIS (AP) — Jordan Binnington was looking for a place to hide. The St. Louis goalie gave up three goals on the first nine shots he faced Tuesday night ... Read more »

Video: CCTV shows portable toilet arson with fireworks in Texas

Explosion damages a building, a trailer and the toilet, but fortunately no one was hurt. Read more »

Suns beat Warriors to match team record with 17th consecutive win despite losing Devin Booker to injury

PHOENIX (AP) — Deandre Ayton scored 24 points, Chris Paul added 15 points and 11 assists, and the Phoenix Suns tied a franchise record of 17 straight wins by beating ... Read more »

Sherfield leads Nevada past Pepperdine 79-66

RENO, Nev. (AP) — Grant Sherfield had 24 points and 10 assists as Nevada beat Pepperdine 79-66 on Tuesday night. Desmond Cambridge Jr. added 21 points for the Wolf Pack. ... Read more »

Japan starts booster COVID vaccinations amid omicron scare

The Associated PressA medical worker of Tokyo Medical Center receives a booster shot of the Pfizer COVID-19 vaccine Wednesday, Dec. 1, 2021 in Tokyo. Japan has started administering the booster ... Read more »

Kyle Rittenhouse says he is destroying the AR-15 rifle he used in Kenosha and doesn't want anything to do with it

Kyle Rittenhouse said during a podcast that he did not want “anything” to do with the firearm he used last August in Kenosha.Mark Hertzberg-Pool/Getty Images Kyle Rittenhouse said on a ... Read more »

Suns win 17th straight by beating Warriors 104-96

PHOENIX (AP) — Deandre Ayton scored 24 points, Chris Paul added 15 points and 11 assists, and the Phoenix Suns tied a franchise record of 17 straight wins by beating ... Read more »

Mariners sign Cy Young winner Robbie Ray to $115M, 5-yr deal

SEATTLE (AP) — AL Cy Young Award winner Robbie Ray and the Seattle Mariners finalized their $115 million, five-year contract Tuesday night. Ray is coming off the best season of ... Read more »

Lakers overcome James' absence to beat Kings 117-92

SACRAMENTO, Calif. (AP) — Anthony Davis scored 25 points, Russell Westbrook added 23 and the Los Angeles Lakers overcame the absence of LeBron James to beat the Sacramento Kings 117-92 ... Read more »

Analysis-Japan keen to speed up digital yen launch as China adds geopolitical twist

FILE PHOTO: A man wearing a protective mask stands in front of the headquarters of the Bank of Japan in Tokyo By Leika Kihara TOKYO (Reuters) – Japan's new political ... Read more »

Gisborne's Tatapouri Bay campsite to allow unvaccinated visitors this summer

In a region with one of the lowest vaccination rates in the country, one campsite has announced all are welcome to visit this summer. This morning Tatapouri Bay campsite in ... Read more »

Pulliam scores 16, Aztecs rout Long Beach State 72-47

SAN DIEGO (AP) — Trey Pulliam scored 16 points, including the first four in an 18-2 run in the first half that gave San Diego State control en route to ... Read more »

95 per cent of people infected with HIV in Mumbai taking treatment: Study

© Provided by Mid-Day About 95 per cent of city residents infected by HIV are aware of their disease status and living with it with treatment, says a survey carried ... Read more »

Bandelier National Monument seeks help finding those who killed elk and mule deer

Dec. 1—Law enforcement rangers at Bandelier National Monument are hoping members of the public can help them track down those responsible for killing an elk and a mule deer on ... Read more »

Capitol riot's 'QAnon Shaman' appeals guilty plea and 41-month prison sentence

WASHINGTON — The Arizona man who wore face paint and horns during the Jan. 6 Capitol riot filed an appeal Tuesday of his guilty plea and sentence of 41 months ... Read more »

Trial to determine if requiring women board members is legal

The Associated PressFILE – Then-California Gov. Jerry Brown talks during an interview in Sacramento, Calif., on Dec. 18, 2018. When former Gov. Brown signed the nation’s first law requiring that ... Read more »

Space junk forces astronauts to delay spacewalk to replace antenna

It’s the first time a spacewalk has been canceled because of a threat from space junk. Read more »

Ohio State ices out No. 1 Duke in final minutes, wins 71-66

COLUMBUS, Ohio (AP) — Zed Key scored a career-high 20 points and Ohio State held top-ranked Duke scoreless for the final 4 1/2 minutes, completing a rally from a 15-point ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic