NFC Championship Game first look: Detroit Lions at San Francisco 49ers odds and lines

Detroit Lions wide receiver Amon-Ra St. Brown celebrates the 31-23 win over the Tampa Bay Buccaneers in the NFC divisional round at Ford Field in Detroit on Sunday, Jan. 21, 2024.

The final 4 teams are set for the NFL’s conference championship weekend. In the NFC Championship Game, the No. 3-seeded Detroit Lions face the top-seeded San Francisco 49ers on the road. They kick off Sunday at 6:30 p.m. ET at Levis Stadium in Santa Clara, CA (FOX). Below, we look at Lions vs. 49ers odds from BetMGM Sportsbook before making our expert NFL picks and predictions later in the week.

The Lions took down the Tampa Bay Buccaneers at home on Sunday 31-23, covering the 6.5-point spread as favorites. After not winning a playoff game in more than 30 years, they have won 2 in a row. They have won 3 straight and 7 of their last 8 overall.

The 49ers rallied from a 21-14 deficit entering the 4th quarter to beat the Green Bay Packers 24-21 at home on Saturday. They were favored by 10.5 points.

FOOTBALL NEVER STOPS

Live games, analysis and more 7 days a week: Get ESPN+

Lions at 49ers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated Sunday at 11:13 p.m. ET.

• Moneyline (ML): Lions +240 (bet $100 to win $240) | 49ers -300 (bet $300 to win $100)
• Against the spread (ATS): Lions +7 (-120) | 49ers -7 (+100)
• Over/Under (O/U): 51 (O: -110 | U: -110)

2023 betting stats

• ML: Lions 14-5 | 49ers 13-5
• ATS: Lions 13-6 | 49ers 9-9
• O/U: Lions 12-7 | 49ers 9-8-1

Lions vs. 49ers head-to-head

They have not played one another since 2021, a 41-33 win by the 49ers in Detroit. Since 1950, the 49ers lead the all-time series 39-28-1 and have won 11 of the last 12 meetings. The Lions’ only win in the last 12 meetings was in 2015, a 32-17 home win.

They have faced each other twice in the postseason, once in 1957 and once in 1983, splitting the 2 games.

49ers QB Brock Purdy lost in the NFC title game a year ago to the Philadelphia Eagles. Lions QB Jared Goff is 1-0 in the NFC title game, making it to the Super Bowl with the Los Angeles Rams after the 2018 season.

Play our free daily Pick’em Challenge and win! Play now!

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

Follow Jess Root on Twitter/X. Follow SportsbookWire on Twitter/X and like us on Facebook.

Access more NFL coverage:

TheHuddle Fantasy Football | BearsWire | BengalsWire | BillsWire | BroncosWire | BrownsWire | BucsWire | CardsWire | ChargersWire | ChiefsWire | ColtsWire | CommandersWire | CowboysWire | DolphinsWire | EaglesWire | FalconsWire | GiantsWire | JaguarsWire | JetsWire | LionsWire | NinersWire | PackersWire | PanthersWire | PatriotsWire | RaidersWire | RamsWire | RavensWire | SaintsWire | SeahawksWire | SteelersWire | TexansWire | TitansWire | VikingsWire | DraftWire | TouchdownWire | ListWire

This article originally appeared on USA Today Sportsbookwire: NFC Championship Game first look: Detroit Lions at San Francisco 49ers odds and lines