A nasal COVID-19 vaccine could be the solution to ending the pandemic, experts say, and early trial data looks promising

Asia's Tech News Daily

Meissa is developing a nasal vaccine against COVID-19. But, it’s still in the earliest phase of human testing. Meissa Vaccines

  • COVID-19 vaccines are great at preventing severe illnesses and death.

  • But they don't always stop transmission, or mild cases.

  • Nasal vaccines could fill that gap.

If we could vaccinate your nose, there's a good chance we'd be able to end this pandemic right now.

But the COVID-19 shots currently available in the US can't control everything that happens in your nostrils. If they did, they might be able to stop all transmission of the virus that happens through our talking, singing, laughing, breathing, and sneezing around each other.

If successful, a new kind of vaccine – a nasal mist that requires no needle – promises to do all that, by providing the special kind of coronavirus immunity people need to stop shuttling this virus around.

“An intra-nasal vaccine could help bring an end to the pandemic, and help give us true control over SARS-CoV-2 by limiting infection and transmission,” Marty Moore, the CEO of Meissa Vaccines, told Insider. “We shouldn't settle for a new normal, we can get back to the old normal.”

For now, that idea remains one that needs much more robust clinical data behind it to become a reality that we could all sniff up. But the prospect is still quite exciting to many immunologists around the world.

Shots in the arm aren't always great at preventing the sniffles

One big reason why vaccine breakthrough infections happen is because the injectable COVID-19 vaccines have been designed to give a person's body good systemic immunity against the virus, protecting internal organs like the lungs and the heart from severe infection. But a shot in the arm can't do as much for your nose in the long run.

If a vaccinated person is exposed to COVID-19, they may still get a case of the sniffles, or a flu-like COVID-19 illness. This is because they haven't developed great mucosal immunity against the coronavirus – in other words: they're still susceptible to infection via the vulnerable moist tissues that interact with the outside world, like those in the nose, eyes, and mouth.

“Very early on during that honeymoon initially after vaccination when your neutralizing antibodies are at their highest, you get a bit of a spillover effect into the upper airway,” Dr. Celine Gounder, an infectious disease specialist at Bellevue hospital in New York, said at the recent ID Week infectious disease conference, explaining the issue of lacking durable mucosal immunity after vaccination.

Meissa is one of a few smaller companies pursuing COVID-19 nasal vaccines in early-stage human trials. Codagenix, another US-based company, has also announced some promising (but extremely small) early trial results. Other nasal vaccines are being developed around the world, with ongoing trials in Israel, Russia, Cuba, India, Hong Kong, and Iran.

“Our aim is to be the transmission-blocking COVID vaccine,” Moore said.

Immunologists are excited about the prospect of nasal vaccines – both for unvaccinated people, and as boosters

According to Meissa's early clinical data (which the company says it will be sharing in more detail at an upcoming immunotherapy conference in late November and early December) unvaccinated patients who are given a couple drops of Meissa's vaccine in each nostril have average mucosal antibody levels slightly higher than those measured in people with natural immunity to the virus.

This suggests that Meissa's vaccine could potentially work well at preventing the more pesky sniffly infections, not just the COVID cases that land people in the hospital.

“It suggests that we can deliver immunity that's like natural infection, but we can do it safely,” Moore said.

This prospect has many immunologists quite excited, not just because nasal vaccines could be offered to vaccine-hesitant people who don't like shots, but also because they might, perhaps, be used as boosters to top up the already very good systemic immunity people have gotten from injectable vaccines.

Meissa's initial human trial is still ongoing now, with 70 participants in it so far. It's only phase 1, meaning any approval or even emergency authorization for this type of vaccine is many months and likely several thousand more volunteer participants away, at best.

But so far, the results look good. Meissa, which is conducting much of its research in Kansas, says there are many reasons why people have chosen to join their early-stage trial.

“Sometimes it's people who are PhDs, or highly educated, who see the benefit of an intra-nasal to prevent infection itself,” Moore said. “And oftentimes, it's people who just don't want a shot. They don't want something injected into them.”

Common side effect complaints after Meissa's nasal vaccine so far have included runny noses, coughs, sore throats, and headaches. But, according to the company, no worrisome safety signals have surfaced with the vaccine, which uses a live-attenuated RSV platform to deliver the coronavirus's characteristic spike protein to vaccinees without risking the coronavirus itself spreading from them.

“There are quite a few people who would rather have drops in the nose than the needle,” Moore said. “So I think an intra-nasal vaccine could reach not all, but many vaccine hesitant people.”

Read the original article on Business Insider

Internet Explorer Channel Network
Asia's Tech News Daily
News Related

OTHER NEWS

2021 hurricane season was third most active

Damage caused by Hurricane Ida at Houma, Louisiana, in September The 2021 Atlantic hurricane season has now officially ended, and it's been the third most active on record. Though the ... Read more »

Spotify Wrapped is here! Talking Tech podcast

Hit play on the player above to hear the podcast and follow along with the transcript below. This transcript was automatically generated, and then edited for clarity in its current ... Read more »

These ancient HP printer security flaws are still exposing 150 models to attack

In a quest to hone their skills by analyzing a HP multifunction printer (MFP), cybersecurity researchers have encountered a couple of bugs that can be exploited to gain remote code ... Read more »

Microsoft is finally dropping a fix for a frustrating Your Phone issue on Surface Duo 2

Microsoft’s Your Phone app is finally getting a fix for one of its more frustrating limitations on the Surface Duo 2: it can now connect to multiple Windows 11 PCs. ... Read more »

5 companies to recall over 57,000 vehicles over faulty parts

SEOUL, Dec. 2 (Yonhap) — Hyundai Motor Co., Nissan Motor Co. and three other companies will voluntarily recall more than 57,000 vehicles to fix faulty components, the transport ministry said ... Read more »

Oil demand, climate change clash in California pipeline plan

The Associated PressFILE – In this May 21, 2015, file photo, workers prepare an oil containment boom at Refugio State Beach, north of Goleta, Calif., two days after an oil ... Read more »

13 earth-friendly toy brands that kids—and parents—love

— Recommendations are independently chosen by Reviewed’s editors. Purchases you make through our links may earn us a commission. While we all want to spoil our kids during the holidays, ... Read more »

Looks like Razer might have its own Steam Deck soon

While we’re still waiting on the Steam Deck, and it seems like Alienware’s Concept UFO is vanished into the aether, it looks like Razer has its own handheld coming up, ... Read more »

If you're taking on student debt to get rich in a professional program, you'll owe more than you earn for years after graduation

© Provided by Business Insider Medical school student. Getty Images The WSJ found 76% of professional programs leave grads with more debt than earnings after 2 years on the job. ... Read more »

AWS wants to make it easier to get to grips with machine learning

Getting to grips with Machine Learning (ML) technology could soon be much easier thanks to a new service from Amazon Web Services. The company has launched Amazon SageMaker Studio Lab, ... Read more »

Conservatives are threatening a government shutdown in 2 days to nix funding for Biden's vaccine mandate — which isn't even in effect yet

© Bill Clark/CQ-Roll Call, Inc via Getty Images Rep. Marjorie Taylor Greene, R-Ga. Bill Clark/CQ-Roll Call, Inc via Getty Images The GOP is threatening to shut down the government to ... Read more »

12 popular places to buy Christmas wreaths, garland and plants online this holiday

— Recommendations are independently chosen by Reviewed’s editors. Purchases you make through our links may earn us a commission. Christmas isn’t Christmas without a good dose of holiday greenery. And ... Read more »

Planning to trade in your iPhone or Android phone? Take these steps first

The first question most of us ask when we’re contemplating a new smartphone: What do I do with my old one? You have plenty of options, of course. Among them ... Read more »

12 holiday gifts that support ethical online shopping

— Recommendations are independently chosen by Reviewed’s editors. Purchases you make through our links may earn us a commission. The holiday season is upon us, and for most people, that ... Read more »

GM cites improved chip supply in raising financial guidance

The Associated PressPresident Joe Biden speaks during a visit to the General Motors Factory ZERO electric vehicle assembly plant, Wednesday, Nov. 17, 2021, in Detroit. (AP Photo/Evan Vucci) DETROIT — ... Read more »

Here's how much US consumers spent per minute on Cyber Monday

The holiday shopping season is far from over but we now know what products were the most popular and exactly how much consumers spent on Cyber Monday 2021 according to ... Read more »

Startup Raises $1.8 Billion in Bid to Generate Fusion Nuclear Energy

Commonwealth Fusion Systems (CFS) has raised more than $1.8 billion, the largest private investment in the nuclear fusion industry as more investors pour money into energy projects that claim limitless energy with ... Read more »

Moderna drops, Arbutus pops after patent ruling means vaccine maker could owe royalties on billions in COVID shot revenue

© Brendan McDermid/Reuters Traders have been cheered by earnings but are still concerned about inflation. Brendan McDermid/Reuters Moderna stock fell 11% on Wednesday after the vaccine maker lost a patent ... Read more »

Goldie Hawn reveals it's been a 'long day' in candid home photo

Goldie Hawn has opened the doors inside her beautiful Los Angeles home to share a candid photo following a “long day”. MORE: Goldie Hawn's daughter-in-law mourns devastating death in emotional ... Read more »

Google Removes Malware Apps That Stole Banking Logins On Android

Google –Alphabet Inc Class A (NASDAQ:GOOGL)– has removed a group of apparently inoffensive apps, which in truth were malware used to steal Android users’ banking logins. According to experts who ... Read more »

Spotify Wrapped 2021: What were your most listened to artists

What was or were your most listened to artists on Spotify this year? December has already begun, and with the month of Christmas comes all the counts and memories of ... Read more »

Oil prices will face downward pressure next year as OPEC sees oversupply expanding, report says

© Getty Images Getty Images Oil markets will start next year with a worsening supply glut, according to an OPEC+ forecast viewed by Reuters. OPEC+ expects a surplus of 2 ... Read more »

The Omicron variant has landed in the US: California just reported its first case

Passengers gather near Delta Air Lines‘ counter as they check their luggage at Hartsfield-Jackson Atlanta International Airport, in Atlanta, Georgia, on May 23, 2021.Reuters/Carlos Barria The Omicron variant is officially ... Read more »

Mathematicians hail breakthrough in using AI to suggest new theorems

Their work examined knot theory and representation theory, areas of "pure mathematics" which typically depend on human intuition for breakthroughs. Read more »

It's time for corporate profits to return to the '90s so companies can make up for decades of underpaying workers, Morgan Stanley says

© Lucy Nicholson/Reuters Lucy Nicholson/Reuters Workers’ share of corporate revenues has fallen for two decades to the benefit of owners and investors. The labor shortage is closing that gap, and ... Read more »

The US Air Force is getting new tech that will make it easier for pilots to pee in flight

© US Air Force A female fighter pilot on an F-35A at Hill Air Force Base. US Air Force The US Air Force is getting new in-flight bladder-relief technology for ... Read more »

One nerdy piece of good news about Omicron: We already have tests that spot signs of the variant

Coronavirus genome sequencing.Camilo Freedman/picture alliance via Getty Images Because of the way the Omicron variant has mutated, some PCR lab tests can provide a good hint that it's around. The ... Read more »

Misinformation fuelled by ‘tsunami' of poor research, says science prize winner

Photograph: Amy Osborne/AFP/Getty Images Dutch microbiologist Elisabeth Bik, winner of prestigious John Maddox prize, says trust in science is being undermined A “tsunami” of poor quality research is fuelling misinformation ... Read more »

A RISC-V Raspberry Pi rival is about to hit the market

Shanghai-based StarFive has announced a new single-board computer (SBC) based on the RISC-V architecture, which is being touted as the spiritual replacement for the cancelled BeagleV. StarFive hails the upcoming ... Read more »

Microsoft is launching a whole new version of Teams

Microsoft is making it even easier for small businesses to use its video conferencing software and online collaboration tool with the launch of the first ever stand-alone version of Microsoft ... Read more »

Liam Gallagher reacts to Oasis tribute band being trapped in pub due to snow: ‘I'm jealous'

Liam Gallagher reacts to Oasis tribute band being trapped in pub due to snow: ‘I’m jealous’ Liam Gallagher has reacted to the news that an Oasis tribute band have been ... Read more »

Former UK chancellor says the Queen asked him to tell Obama to leave a state banquet because she wanted to go to bed

Queen Elizabeth II and then-President Barack Obama in the Music Room of Buckingham Palace ahead of a 2011 state banquet.Chris Jackson/AFP via Getty Images George Osborne said the Queen once ... Read more »

Sheridan Smith is ‘lucky to be alive' after ‘crashing car into tree'

Sheridan Smith is “lucky to be alive” after being involved in an car crash, it’s been reported. It’s being claimed that the actor and singer was driving her Range Rover ... Read more »

UK weather: More snow forecast as temperatures plunge again

People walk along a road in Buxton after Storm Arwen, Buxton, Derbyshire, Britain, November 29, 2021. (REUTERS) Snow is forecast across parts of England and Scotland over the next four ... Read more »

Strictly Come Dancing's Rhys Stephenson Defends Host Tess Daly Over 'Crying' Comments

Rhys Stephenson and Tess Daly (Photo: BBC) Strictly Come Dancing star Rhys Stephenson has defended the show’s host Tess Daly over comments she made about him crying on last week’s ... Read more »

Mysteries of omicron variant could take weeks to untangle

1 / 4Virus Outbreak-Omicron UnknownsFILE – A worker disinfects chairs at a new vaccination center in Lisbon, Tuesday, Nov. 30, 2021. A pandemic-weary world faces weeks of confusing uncertainty as ... Read more »

Fintechs helped Black-owned small businesses get access to PPP loans during the pandemic more than banks did. It's weird.

© Provided by Business Insider JJ Gouin/Getty Images The Paycheck Protection Program was a lifeline for businesses during the pandemic. But it seems not every small business could easily turn ... Read more »

The government's response to making homeownership more attainable is buying $1 million mortgages

© Newsday LLC / Contributor/Getty Images Everyone wants a house right now, and that means Fannie Mae and Freddie Mac have to pay up. Newsday LLC / Contributor/Getty Images Fannie ... Read more »

Millennials are blaming boomers for the starter home shortage, survey finds

© Provided by Business Insider Millennials and boomers are in a housing war for starter homes. Allen J. Schaben/Getty Images Some millennials blame boomers for the starter home shortage, a ... Read more »

Spotify Wrapped 2021 has now arrived - here's how to access it

It’s that time of the year again – Spotify Wrapped has finally arrived. Each year Spotify’s round-up of music tastes seems to take over social media for a few days, ... Read more »
On free-english-test.com you will find lots of free English exam practice materials to help you improve your English skills: grammar, listening, reading, writing, ielts, toeic